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Evidence found and GRADE certainty

859 questions · 901 findings · 80 reviews

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No studies found 247 · 27.4%GRADE not reported 170 · 18.9%Very low 224 · 24.9%Low 136 · 15.1%Moderate 90 · 10%High 34 · 3.8%

Adhesive precoated (APC) flash-free brackets (minimal excess adhesive) vs Conventional ceramic brackets

Enamel demineralization (DIAGNOdent score) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Adhesive precoated flash-free brackets showed no demineralization difference, with certainty not graded.

1 finding from 1 review

Adhesive precoated (APC) flash-free brackets (minimal excess adhesive) vs Conventional brackets

White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)

Two studies found adhesive flash-free brackets did not clinically reduce enamel demineralization or white spot lesions versus conventional brackets, though they reduced pathogenic bacteria (ungraded).

1 finding from 1 review

Summary of findings table ‐ mesh repair vs non‐mesh repair

Surgical site infection · adult patients with incarcerated or strangulated groin hernia

It is very uncertain whether summary of findings table ‐ mesh repair changes surgical site infections within 30 days of repair compared with non‐mesh repair (very low certainty).

1 finding from 1 review

Summary of findings table ‐ mesh repair vs non‐mesh repair

Mortality within 30 days of repair · adult patients with incarcerated or strangulated groin hernia

It is very uncertain whether summary of findings table ‐ mesh repair changes mortality within 30 days of repair compared with non‐mesh repair (very low certainty).

1 finding from 1 review

Summary of findings table ‐ mesh repair vs non‐mesh repair

Clinical recurrence or reoperation for recurrence within one year of repair · adult patients with incarcerated or strangulated groin hernia

It is very uncertain whether summary of findings table ‐ mesh repair changes clinical recurrence or reoperation for recurrence within one year of… compared with non‐mesh repair (very low certainty).

1 finding from 1 review

Inflammatory bowel disease (IBD) vs Healthy controls without IBD

DMFT/DMFS index (dental caries experience) · Patients with IBD (Crohn's disease and ulcerative colitis) and controls without IBD

Most included studies reported higher dental caries indices (DMF-t/DMF-s) in IBD patients (especially ulcerative colitis), but findings were inconsistent across studies and were not meta-analyzed or GRADE-rated.

1 finding from 1 review
  • Oral Health Status in Patients with Inflammatory Bowel Diseases: A Systematic Review. 2021 All outcomes
    Hospital/clinic-based case-control and cross-sectional studies in 11 countries; 15 studies total (1748 participants: 1104 Crohn's disease, 534 ulcerative colitis, 110 IBD-form unspecified)
    Not meta-analyzed (heterogeneity of caries indices). Abstract: "in most studies, patients with IBD were characterized by higher values of caries indices." Table 3 examples (IBD/subtype vs control): Zhang 2020 DMF-t…
    Studies not reported
    GRADE not reported

Psychological interventions vs usual care

Proportion of wounds healed · adults with diabetes with current or previous foot ulceration

It is very uncertain whether psychological intervention changes proportion of wounds completely healed at 3 months compared with standard care (very low certainty).

2 findings from 1 review

Psychological interventions vs usual care

Number of foot ulcer recurrences · adults with diabetes with current or previous foot ulceration

It is very uncertain whether psychological intervention changes number of foot ulcer recurrences at 1 year compared with standard care (very low certainty).

2 findings from 1 review

Psychological interventions vs Other Psychological Interventions

Proportion of wounds healed · adults with diabetes with current or previous foot ulceration

It is very uncertain whether psychological intervention changes proportion of wounds completely healed at 3 months compared with another psychological intervention (very low certainty).

1 finding from 1 review