Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,271 questions · 1,326 findings · 329 reviews

No studies found 247 · 18.6%GRADE not reported 237 · 17.9%Very low 379 · 28.6%Low 285 · 21.5%Moderate 141 · 10.6%High 37 · 2.8%

Radix Sophorae flavescentis vs placebo or no intervention

Non‐serious adverse events Maximum · chronic hepatitis B

It is very uncertain whether radix Sophorae flavescentis changes proportion of participants with 1 or more adverse events considered… compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Acupuncture vs no intervention

Proportion of participants with 1 or more serious adverse events · chronic hepatitis B

The review found no eligible studies for this question.

1 finding from 1 review

Acupuncture vs no intervention

Non‐serious adverse events Maximum · chronic hepatitis B

It is very uncertain whether acupuncture changes proportion of participants with 1 or more adverse events considered… compared with no intervention (very low certainty).

1 finding from 1 review

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

Additional drugs required to terminate the seizure: 2 or more additional anticonvulsants required · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intranasal lorazepam may leads to lower additional drugs required to terminate the seizure: 2 or more… compared with intramuscular paraldehyde (low certainty).

1 finding from 1 review

Exercise vs no exercise

Pain ‐ long term (12 months and beyond) Pain subscale of Michigan Hand Outcomes Questionnaire (0 to 100 points, higher score means more pain) · rheumatoid arthritis of the hand
1 finding from 1 review

Intervention not reported

Primary outcome 2: participant‐ or parent‐rated participant quality of life score at the end of active treatment Scales used: DLQI, IDQoL, Skindex‐29, CDLQI. On those scales, the higher the score, the more severely the quality of life is affected ... · male and female patients 0 to 55 years of age with physician‐diagnosed eczema
1 finding from 1 review

Intervention not reported

Primary outcome 2: participant‐ or parent‐rated family quality of life score at the end of active treatment Scale used: DFI, FDLQI. On those scales, the higher the score, the more severely the quality of life is affected Duration of · male and female patients 0 to 55 years of age with physician‐diagnosed eczema
1 finding from 1 review

Intervention not reported

Secondary outcome 4: global eczema severity score (total SCORAD) at the end of active treatment (Investigator‐rated eczema severity) Scale used: total SCORAD ranging from 0 to 103. The higher the score, the more severe the disease Duration of · male and female patients 0 to 55 years of age with physician‐diagnosed eczema
1 finding from 1 review

ARIPIPRAZOLE (IM) vs haloperidol

Adverse effects: one or more adverse events during 24 hours (only reported if occurred in ≥ 5% of people) · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether ARIPIPRAZOLE (IM) changes adverse effects: one or more adverse events during 24 hours (only… compared with OTHER ANTIPSYCHOTIC: a. HALOPERIDOL (very low certainty).

1 finding from 1 review

ARIPIPRAZOLE (IM) vs OLANZAPINE

Adverse effects: one or more adverse effects during 24 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether ARIPIPRAZOLE (IM) changes adverse effects: one or more adverse effects during 24 hours compared with OTHER ANTIPSYCHOTIC: b. OLANZAPINE (very low certainty).

1 finding from 1 review

ARIPIPRAZOLE (IM) vs PLACEBO/NIL

Adverse effects: one or more adverse events during 24 hours (only reported if occurred in ≥ 5% of people) · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether ARIPIPRAZOLE (IM) changes adverse effects: one or more adverse events during 24 hours (only… compared with PLACEBO/NIL (very low certainty).

1 finding from 1 review

Cognitive‐behavioural coping skills training (CBCST) vs Twelve Step Facilitation

Number of participants achieving 3 or more weeks of consecutive alcohol abstinence during treatment · concurrent problem alcohol and illicit drug users

It is very uncertain whether cognitive‐behavioural coping skills training (CBCST) changes number of participants achieving 3 or more weeks of consecutive… compared with twelve‐step facilitation (TSF) programme to reduce alcohol consumption (very low certainty).

1 finding from 1 review