What do systematic reviews say?

Tinzaparin vs placebo

The review found no eligible studies for this question.

• Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

ANY FORM OF BRIEF PSYCHOEDUCATION vs usual care

ANY FORM OF BRIEF PSYCHOEDUCATION probably leads to lower compliance: 1a. With medication ‐ non‐compliance ‐ short term compared with for ROUTINE CARE/INFORMATION (moderate certainty).

• Psychoeducation (brief) for people with serious mental illness 2015 · Cochrane Headline outcomes only
  RR 0.63 [0.41, 0.96]
  3 studies · 448 participants
  Moderate

ANY FORM OF BRIEF PSYCHOEDUCATION vs CBT

• Psychoeducation (brief) for people with serious mental illness 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 88 participants
  Very low

Intervention not reported

• Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 589 participants
  Low

SSRIs or SNRIs vs other antidepressants

• Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 152 participants
  Low

SSRIs or SNRIs vs placebo

• Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 118 participants
  Low

Intraoperative 5‐Fluorouracil vs placebo or control

Intraoperative 5‐Fluorouracil leads to lower failure at 12 months Need for repeat surgery or uncontrolled IOP… compared with placebo or control (high certainty).

• 5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
  RR 0.68 [0.51, 0.92]
  4 studies · 711 participants
  High

FLUPENTHIXOL DECANOATE vs other depot antipsychotic drugs

FLUPENTHIXOL DECANOATE showed no clear difference in adverse effects: general ‐ movement disorders ‐ requiring… compared with OTHER DEPOT ANTIPSYCHOTICS (low certainty).

• Flupenthixol decanoate (depot) for schizophrenia or other similar psychotic disorders 2014 · Cochrane Headline outcomes only
  RR 1.38 [0.75, 2.52]
  3 studies · 102 participants
  Low

FLUPENTHIXOL DECANOATE HIGH DOSE vs FLUPENTHIXOL DECANOATE STANDARD DOSE (˜40 mg/IM)

• Flupenthixol decanoate (depot) for schizophrenia or other similar psychotic disorders 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 47 participants
  Very low

FLUPENTHIXOL DECANOATE VERY LOW (˜6 mg/IM) DOSE vs FLUPENTHIXOL DECANOATE LOW DOSE (˜9 mg/IM)

The review found no eligible studies for this question.

• Flupenthixol decanoate (depot) for schizophrenia or other similar psychotic disorders 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

FLUPENTHIXOL DECANOATE vs GENERAL ORAL ANTIPSYCHOTICS

It is very uncertain whether FLUPENTHIXOL DECANOATE changes adverse effects: general ‐ movement disorders ‐ requiring… compared with ORAL ANTIPSYCHOTICS (very low certainty).

• Flupenthixol decanoate (depot) for schizophrenia or other similar psychotic disorders 2014 · Cochrane Headline outcomes only
  RR 1.19 [0.77, 1.83]
  1 study · 60 participants
  Very low

Perazine vs OTHER ANTIPSYCHOTICS

It is very uncertain whether perazine changes movement disorders number of participants receiving antiparkinson… compared with other antipsychotics (very low certainty).

• Perazine for schizophrenia 2014 · Cochrane Headline outcomes only
  RR 1.21 [0.53, 2.76]
  2 studies · 81 participants
  Very low

Perazine vs placebo

It is very uncertain whether perazine changes movement disorders number of participants receiving antiparkinson… compared with placebo (very low certainty).

• Perazine for schizophrenia 2014 · Cochrane Headline outcomes only
  RR 4.5 [1.04, 19.45]
  1 study · 95 participants
  Very low

LABA/ICS vs LTRA + ICS

• Addition to inhaled corticosteroids of long‐acting beta₂‐agonists versus anti‐leukotrienes for chronic asthma 2014 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 4055 participants
  High

BRIEF FAMILY INTERVENTION vs usual care

The review found no eligible studies for this question.

• Family intervention (brief) for schizophrenia 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Bronchial thermoplasty vs active control

• Bronchial thermoplasty for moderate or severe persistent asthma in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 429 participants
  Low

INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) FOR PROMPTING/SUPPORT + STANDARD CARE vs usual care

INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) FOR PROMPTING/SUPPORT… showed no clear difference in compliance with medication: Would stop taking medication Morisky… compared with STANDARD CARE (moderate certainty).

• Information and communication technology based prompting for treatment compliance for people with serious mental illness 2014 · Cochrane Headline outcomes only
  RR 1.11 [0.96, 1.29]
  1 study · 320 participants
  Moderate

Comparison of water‐based exercise vs control

• Water‐based exercise for adults with asthma 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  Very low

COMPARISON 1. ARIPIPRAZOLE vs placebo

Aripiprazole leads to higher requirement for anticholinergics number of participants requiring… compared with placebo (high certainty).

• Aripiprazole alone or in combination for acute mania 2013 · Cochrane Headline outcomes only
  RR 3.28 [1.82, 5.91]
  730 participants
  High

QUETIAPINE vs CLOZAPINE ‐ all data short term

• Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 28 participants
  Low