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Evidence found and GRADE certainty

2,745 questions · 4,389 findings · 203 reviews · Oral Health

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No studies found 39 · 0.9%GRADE not reported 3,844 · 87.6%Very low 198 · 4.5%Low 137 · 3.1%Moderate 134 · 3.1%High 37 · 0.8%

Children with dental caries vs Children without dental caries

Serum ferritin (ng/mL) · Children or adolescents

Serum ferritin tends to be lower in children with dental caries, but the pooled difference is not statistically significant (MD -3.96, 95% CI -8.48 to 0.57; very low certainty).

1 finding from 1 review

Hydroxyapatite (e.g., nano-HAp) vs Mesoporous silica (SiO2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, HAp vs Silica showed no significant difference in 24 h bond strength (MD -3.756, 95% CI -10.536 to 3.024; Moderate certainty).

1 finding from 1 review

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Femur fracture · European-ancestry adults

Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of femur (multivariable MR, OR 1.069).

2 findings from 1 review

Out-of-pocket health expenditure vs Lower vs higher out-of-pocket expenditure categories

Oral health-related quality of life · people aged 60 years and older living in the community

Lower out-of-pocket health expenditure was associated with better OHRQoL (83.9, 95% CI 75.2 to 92.6 vs 67.5, 95% CI 58.5 to 76.5); the difference was statistically significant (ungraded).

2 findings from 1 review

Lactobacillus-derived postbiotics vs Not specified

Virulence-gene expression related to adhesion acid production and exopolysaccharide synthesis · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro

No meta-analysis was conducted; the narrative synthesis reported reduced expression of Streptococcus mutans virulence genes.

1 finding from 1 review

Unilateral cleft lip and palate (UCLP) vs Bilateral cleft lip and palate (BCLP)

Plaque · Patients with cleft lip and palate (CLP)

Plaque index does not differ significantly between unilateral and bilateral cleft lip and palate (MD -0.13, 95% CI -0.38 to 0.12; ungraded).

1 finding from 1 review

Genetically predicted pulp and periapical diseases vs Without pulp and periapical diseases (lower genetic liability)

Lacunar stroke · European-ancestry adults

Genetically predicted pulp and periapical diseases were associated with modestly higher odds of lacunar stroke (OR 1.20); ungraded MR, FDR-adjusted P 0.033.

1 finding from 1 review

Machine-learning algorithms for dental caries detection vs Dental expert / visual-tactile clinical assessment (reference standard)

Positive post-test probability · Dental images or diagnostic tests for dental caries detection

The positive post-test probability was 79%; certainty was not graded.

1 finding from 1 review

Electronic cigarette use vs Non-smokers

IL-8 level · People who use electronic cigarettes

The review reports that GCF evidence was limited and may show a potential association.

3 findings from 1 review

Microinvasive techniques (resin infiltration or glass ionomer varnish) vs Non-invasive measures (fluoride varnish/toothpaste, flossing, oral hygiene instruction, sham/standard of care)

Radiographic proximal caries lesion progression · Children with non-cavitated proximal caries lesions in primary teeth (ages 3-9)

In primary teeth (5 trials), microinvasive techniques reduced radiographic proximal caries progression versus non-invasive measures (OR 0.38; ungraded subgroup).

1 finding from 1 review