Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,661 questions · 2,751 findings · 453 reviews

No studies found 593 · 21.6%GRADE not reported 277 · 10.1%Very low 538 · 19.6%Low 712 · 25.9%Moderate 516 · 18.8%High 115 · 4.2%

Intervention not reported

Thrombotic events at longest · hospitalised adults with COVID‐19 (moderate to severe disease)

The intervention showed no clear difference in thrombotic events at longest (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events at longest · hospitalised adults with COVID‐19 (moderate to severe disease)

The intervention showed no clear difference in serious adverse events at longest (low certainty).

1 finding from 1 review

Intervention not reported

Major bleeding events at longest · hospitalised adults with COVID‐19 (moderate to severe disease)

The intervention probably leads to higher major bleeding events at longest (moderate certainty).

1 finding from 1 review

Intervention not reported

Episodes of bradycardia, defined as a fall in heart rate of more than 30% below the baseline or less than 100 beats per minute for 10 seconds or longer, occurring during the procedure · Procedural pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Adenoidectomy and unilateral ventilation tube vs unilateral ventilation tube only

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and unilateral ventilation tube changes presence or persistence of OME (3 years ‐ long‐term) № of… compared with unilateral ventilation tube only (very low certainty).

1 finding from 1 review

Adenoidectomy and ventilation tubes vs watchful waiting

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and ventilation tubes changes presence/persistence of OME (at 2 years ‐ long‐term) № of… compared with no treatment/watchful waiting (very low certainty).

1 finding from 1 review

Intervention not reported

Quality of life up to 28 days and longest · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

All initial symptoms resolved at 28 days, and up to the longest · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Quality of life up to 28 days and longest · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The review found no eligible studies for this question.

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Long‐term any stroke · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes any stroke (fatal or non‐fatal; contralateral, ipsilateral or… compared with primary closure (very low certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Long‐term ipsilateral stroke · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes ipsilateral stroke (fatal or non‐fatal; haemorrhage or infarct)… compared with primary closure (very low certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Long‐term stroke or death · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes any stroke or death during long‐term compared with primary closure (very low certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Restenosis (> 50%) or occlusion of operated artery during long‐term · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

Main comparison of patch angioplasty may leads to lower restenosis (> 50%) or occlusion of operated artery during long‐term compared with primary closure (low certainty).

1 finding from 1 review