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Evidence found and GRADE certainty

1,281 questions · 1,307 findings · 212 reviews

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No studies found 256 · 19.6%GRADE not reported 125 · 9.6%Very low 266 · 20.4%Low 403 · 30.8%Moderate 208 · 15.9%High 49 · 3.7%

Intervention not reported

Premedication given ‐ no premedication given: first intubation attempt success rate (outcome achieved at time of intubation attempt and not followed up) · neonates requiring endotracheal intubation

The intervention showed no clear difference in premedication given ‐ no premedication given: first intubation… (moderate certainty).

1 finding from 1 review

Vibratory stimulation (vibratory adjuncts) vs No vibration or placebo vibration

Dose/intensity and frequency of pain relief needed (analgesic/rescue medication use) · Adolescents and adults undergoing orthodontic treatment

Vibratory stimulation (vibratory adjuncts) led to lower dose/intensity and frequency of pain relief needed (analgesic/rescue… compared with no vibration or placebo vibration; GRADE not reported.

1 finding from 1 review

Droperidol vs midazolam

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol showed no clear difference in global state: use of additional medication ‐ by 60 minutes after… compared with midazolam (moderate certainty).

1 finding from 1 review

Droperidol vs placebo

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with placebo (high certainty).

1 finding from 1 review

Droperidol vs OLANZAPINE

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with olanzapine (high certainty).

1 finding from 1 review

Droperidol vs haloperidol

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with haloperidol (high certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE)

Adverse events: Movement disorder requiring the use of anti‐EPS medication ‐ medium term · patients with schizophrenia

RISPERIDONE DEPOT probably leads to higher adverse events: Movement disorder requiring the use of anti‐EPS… compared with ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE) (moderate certainty).

1 finding from 1 review

Primary care physician alerting system and a patient‐directed intervention (education and reminder to see their primary care physician) vs usual care

Osteoporosis medication 2 · General practitioners/family doctors involved in the management of patients with osteoporosis

Primary care physician alerting system and a patient‐directed… leads to higher osteoporosis medication 2 compared with standard care (high certainty).

1 finding from 1 review

Primary care physician alerting system vs usual care

Osteoporosis medication2 · General practitioners/family doctors involved in the management of patients with osteoporosis

Primary care physician alerting system probably leads to higher osteoporosis medication2 compared with usual care (moderate certainty).

1 finding from 1 review