Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,121 questions · 2,186 findings · 242 reviews

No studies found 493 · 22.6%GRADE not reported 158 · 7.2%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.7%High 97 · 4.4%

Antibiotics vs placebo or no treatment

Clinical treatment failure (Persistent or worsening symptoms at the end of treatment) · patients symptomatic for NTS infection

It is very uncertain whether antibiotics changes clinical treatment failure (Persistent or worsening symptoms at the… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Diarrhoea · patients symptomatic for NTS infection

It is very uncertain whether antibiotics changes presence of diarrhoea at 2‐4 days compared with placebo or no treatment (very low certainty).

2 findings from 1 review

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

All‐cause mortality · hospital‐acquired pneumonia

Should short‐course antibiotic therapy showed no clear difference in mortality compared with prolonged‐course antibiotic therapy be used (moderate certainty).

1 finding from 1 review

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Mortality NF‐GNB · hospital‐acquired pneumonia

Should short‐course antibiotic therapy showed no clear difference in mortality NF‐GNB compared with prolonged‐course antibiotic therapy be used (low certainty).

1 finding from 1 review

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Mortality MRSA · hospital‐acquired pneumonia

Should short‐course antibiotic therapy showed no clear difference in mortality MRSA compared with prolonged‐course antibiotic therapy be used (moderate certainty).

1 finding from 1 review

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Recurrence of pneumonia · hospital‐acquired pneumonia

Should short‐course antibiotic therapy showed no clear difference in recurrence of pneumonia Clinical and/or microbiological criteria compared with prolonged‐course antibiotic therapy be used (low certainty).

1 finding from 1 review

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Recurrence of pneumonia ‐ NF‐GNB · hospital‐acquired pneumonia

Should short‐course antibiotic therapy probably leads to higher recurrence of pneumonia NF‐GNB Clinical and/or microbiological… compared with prolonged‐course antibiotic therapy be used (moderate certainty).

1 finding from 1 review

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Recurrence of pneumonia ‐ MRSA · hospital‐acquired pneumonia

Should short‐course antibiotic therapy showed no clear difference in recurrence of pneumonia MRSA Clinical and/or microbiological criteria compared with prolonged‐course antibiotic therapy be used (moderate certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Clinical diagnosis of leptospirosis regardless of laboratory confirmation · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes clinical diagnosis of leptospirosis regardless of laboratory… compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Laboratory‐confirmed leptospirosis · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes clinical diagnosis of leptospirosis confirmed by laboratory diagnosis compared with other antibiotics (very low certainty).

2 findings from 1 review

Antibiotics vs other antibiotics

Non‐serious adverse events · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes non‐serious adverse events compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Adverse events considered non‐serious (penicillin versus cefotaxime) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious (penicillin versus cefotaxime) compared with other antibiotics (very low certainty).

1 finding from 1 review