Cochrane · systematic review · CD007577
Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults
Pugh, R, Grant, C, Cooke, RPD, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 4 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsShould short‐course antibiotic therapy versus prolonged‐course antibiotic therapy be used in critically ill patients with hospital‐acquired pneumonia?
Population: hospital‐acquired pneumonia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Should short‐course antibiotic therapy vs prolonged‐course antibiotic therapy be used | OR 1.18 [0.77, 1.8] | 3 studies · 598 participants | Moderate |
Mortality NF‐GNB Should short‐course antibiotic therapy vs prolonged‐course antibiotic therapy be used | OR 0.95 [0.39, 2.27] | 2 studies · 179 participants | Low |
Mortality MRSA Should short‐course antibiotic therapy vs prolonged‐course antibiotic therapy be used | OR 1.28 [0.32, 5.09] | 1 study · 42 participants | Moderate |
Recurrence of pneumonia Clinical and/or microbiological criteria Should short‐course antibiotic therapy vs prolonged‐course antibiotic therapy be used | OR 1.41 [0.94, 2.12] | 19 studies · 733 participants | Low |
Recurrence of pneumonia NF‐GNB Clinical and/or microbiological criteria Should short‐course antibiotic therapy vs prolonged‐course antibiotic therapy be used | OR 2.18 [1.14, 4.16] | 2 studies · 176 participants | Moderate |
Recurrence of pneumonia MRSA Clinical and/or microbiological criteria Should short‐course antibiotic therapy vs prolonged‐course antibiotic therapy be used | OR 1.56 [0.12, 19.61] | 2 studies · 49 participants | Moderate |
28‐day antibiotic‐free days Should short‐course antibiotic therapy vs prolonged‐course antibiotic therapy be used | no estimate extracted | 2 studies · 431 participants | Low |