Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Periodontitis (clinical attachment loss) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste showed no clear difference in periodontitis at 36 months (attachment loss > 0 mm) compared with fluoride toothpaste without triclosan (low certainty).

1 finding from 1 review

No dentinal caries removal (caries sealed under a preformed metal crown or restoration without removing dentinal caries) vs Complete caries removal

Signs or symptoms of pulpal disease · Patients with carious teeth, affecting any tooth surface(s), in unrestored primary and permanent teeth

No dentinal caries removal (caries sealed under a preformed metal… showed no clear difference in signs or symptoms of pulpal disease compared with complete caries removal (moderate certainty).

1 finding from 1 review

Hyperbaric oxygen vs No HBO therapy

Postimplantation complications · Patients who have had radiotherapy and who have missing teeth that require replacement with osseointegrated dental implants

Hyperbaric oxygen (HBO) therapy showed no clear difference in postimplantation complications compared with no HBO therapy; GRADE not reported.

1 finding from 1 review

Locking plate vs 2 mm non-locking titanium plates

Restoration of function (functional occlusion; bite force as surrogate) · Adults (16 to 68 years) with mandibular fractures excluding condylar involvement
1 finding from 1 review
  • Functional occlusion was achieved in all participants in both intervention groups (Agarwal 2011); the measurement of this outcome was not clearly reported. Bite force was reported as a surrogate/proxy outcome.
    1 study
    GRADE not reported

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Implant failure · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) probably leads to lower implant failure compared with no antibiotics or placebo (moderate certainty).

1 finding from 1 review

One microplate plus one miniplate vs Two miniplates

Efficacy and stability of fixation (bite force) · Adults with isolated mandibular fractures in the interforaminal region
1 finding from 1 review
  • Only one study (Gupta 2012) compared one microplate in conjunction with one miniplate versus two miniplates in isolated interforaminal fractures; however, the data reported in the trial did not satisfy the review's…
    1 study
    GRADE not reported

Fixation (splinting) vs No splint, or a different type or duration of splint

Outcome not reported · Patients (mainly children and young adults) with a history of dental trauma and a diagnosis of luxation (intrusion, extrusion, or lateral…

The review found no eligible studies for this question.

1 finding from 1 review

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Adverse events · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
1 finding from 1 review

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Periodontitis (clinical attachment loss) · Adults, 16 years and older (dentate)

The review found no eligible studies for this question.

1 finding from 1 review

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

Assessment of the alignment of the lower front teeth using any method or index · Participants who previously underwent orthodontic treatment, with subsequent crowding (relapse) of the lower front teeth (lower incisors…

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Adverse events · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.

1 finding from 1 review

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

Decay (decalcification) associated with or around the etching field · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars
1 finding from 1 review
  • Decay (decalcification) associated with or around the etching field: Only one study (Ghiz 2009) assessed this outcome but data were reported at the tooth level rather than at the participant level and therefore was not…
    1 study · 25 participants
    GRADE not reported

Extraction of the primary maxillary canine vs no intervention

Time to eruption of the permanent canine · Children with palatally displaced maxillary canines (at least 80% aged 10 to 13 years); trials with craniofacial syndromes or anomalies…
1 finding from 1 review