Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,938 questions · 1,994 findings · 246 reviews · Headline outcomes only

No studies found 490 · 24.6%GRADE not reported 71 · 3.6%Very low 669 · 33.6%Low 446 · 22.4%Moderate 264 · 13.2%High 54 · 2.7%

Sinonasal debridement vs no debridement

Postoperative endoscopic appearance of the sinonasal surgical cavities: Lund‐Kennedy endoscopic score (range 1 to 10) · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

Sinonasal debridement showed no clear difference in postoperative endoscopic appearance of the sinonasal surgical… compared with no debridement (low certainty).

1 finding from 1 review

Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery

Number of participants with major bleeding within 7 days of surgery (surgical site bleeding requiring a second intervention or reoperation or surgical site bleeding that causes a haematoma or haemarthrosis of sufficient size to delay mobilisation ... · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes number of participants with major bleeding within 7 days of surgery… compared with no prophylactic platelet transfusion prior to surgery (very low certainty).

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Hysterectomy to control bleeding · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid showed no clear difference in surgical intervention to control bleeding: Hysterectomy compared with placebo or standard care alone (high certainty).

1 finding from 1 review

Misoprostol vs surgery

Unplanned surgical intervention · incomplete miscarriage

Misoprostol may leads to higher unplanned surgical intervention compared with surgery (low certainty).

1 finding from 1 review

Misoprostol vs surgery

Surgical evacuation · incomplete miscarriage

It is very uncertain whether misoprostol changes surgical evacuation compared with surgery (very low certainty).

1 finding from 1 review

Intervention not reported

Direct surgical morbidity · women with stage I endometrial cancer

The intervention showed no clear difference in direct surgical morbidity (moderate certainty).

1 finding from 1 review

Laparaoscopic radical prostatectomy and robotic‐assisted laparoscopic radical prostatectomy vs open radical prostatectomy

Overall rate of surgical complications

Laparaoscopic radical prostatectomy and robotic‐assisted… showed no clear difference in overall surgical complications (short‐term) compared with open radical prostatectomy (low certainty).

1 finding from 1 review

Acupuncture vs topical antibiotics

Participants who required surgical incision and drainage after the treatment period or seven days after diagnosis · people with acute hordeolum

The review found no eligible studies for this question.

1 finding from 1 review

Pancreaticojejunostomy vs pancreatogastrostomy after pancreatoduodectomy

Rate of surgical re‐intervention: TEG or ROTEM vs control · adults undergoing pancreatoduodenectomy (mainly for pancreatic cancer)

Pancreaticojejunostomy showed no clear difference in surgical re‐intervention compared with pancreatogastrostomy after pancreatoduodectomy (low certainty).

1 finding from 1 review