Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

681 questions · 709 findings · 179 reviews

No studies found 180 · 25.4%GRADE not reported 51 · 7.2%Very low 194 · 27.4%Low 144 · 20.3%Moderate 110 · 15.5%High 30 · 4.2%

Film dressing vs exposed wound

Acceptability of dressing to participant · surgical wounds resulting from clean surgery and healing by primary intention

It is very uncertain whether film dressing changes acceptability of dressing to participant compared with exposed wound (very low certainty).

1 finding from 1 review

Topiramate as add‐on therapy vs placebo

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate as add‐on therapy showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).

1 finding from 1 review

Topiramate as monotherapy vs alternative drug

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate as monotherapy showed no clear difference in acceptability with topiramate (12 weeks) Number of participants… compared with an alternative drug (low certainty).

1 finding from 1 review

Topiramate as add‐on therapy vs alternative drug

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

It is very uncertain whether topiramate as add‐on therapy changes acceptability with topiramate (8 weeks) Number of participants… compared with alternative drug (very low certainty).

1 finding from 1 review

Topiramate vs placebo

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).

1 finding from 1 review

Surgery vs oral medication

Control of bleeding (cure or improvement to acceptable level) At 2 years · women with heavy menstrual bleeding

Surgery probably leads to higher control of bleeding (cure or improvement to acceptable level) At 4… compared with oral medication (moderate certainty).

3 findings from 1 review

VALPROATE + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

It is very uncertain whether VALPROATE + ANTIPSYCHOTICS changes leaving the study early: Acceptability of treatment Leaving the… compared with ANTIPSYCHOTICS + PLACEBO or ANTIPSYCHOTICS alone (very low certainty).

1 finding from 1 review

Intervention not reported

LARC uptake by 4 weeks; LARC use at 3 months · women with need for contraception

The intervention probably leads to higher LARC uptake by 4 weeks; LARC use at 3 months (moderate certainty).

1 finding from 1 review

Mobile clinics vs static clinics

Health behaviour: self‐reported mammography uptake ( · women aged 60 to 84 years at study entry. (Age of participants matches our selection criteria)

Mobile clinics may leads to higher health behaviour: self‐reported mammography uptake ( compared with static clinics (low certainty).

1 finding from 1 review

Intervention not reported

Chlamydia prevalence (general population) Outcome was chlamydia test positivity after 3 yearly invitations in intervention clusters vs 1 invitation in control areas. Uptake was too low for chlamydia positivity to be considered an unbiased estimate... · healthy adults

The intervention showed no clear difference in chlamydia prevalence (general population) Outcome was chlamydia test… (low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults

S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).

1 finding from 1 review