Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

542 questions · 578 findings · 107 reviews

No studies found 32 · 5.5%GRADE not reported 76 · 13.1%Very low 155 · 26.8%Low 150 · 26%Moderate 144 · 24.9%High 21 · 3.6%

Intervention not reported

Rate of participation [case notes or questionnaire, measured immediately or up to four weeks post‐intervention] · people with a health condition (or pregnant) considering real clinical trial participation (across a range of topic areas)

The intervention may leads to lower rate of participation [case notes or questionnaire, measured… (low certainty).

1 finding from 1 review

Intervention not reported

Anxiety (or other psychological stress) [Spielberger State and Trait Anxiety score, measured immediately post‐intervention] · people with a health condition (or pregnant) considering real clinical trial participation (across a range of topic areas)

The intervention may leads to lower anxiety (or other psychological stress) [Spielberger State and Trait… (low certainty).

1 finding from 1 review

Intervention not reported

Knowledge [questionnaire (scored out of 80), measured immediately post‐intervention] · people with a health condition or nominally 'well' considering real or hypothetical clinical trial participation in cancer or psychiatric…

The intervention may leads to lower knowledge [questionnaire (scored out of 80), measured immediately… (low certainty).

1 finding from 1 review

Intervention not reported

Knowledge [scored correct answer to single question, measured immediately post‐intervention] · people with a health condition or nominally 'well' considering real or hypothetical clinical trial participation in cancer or psychiatric…

The intervention showed no clear difference in knowledge [scored correct answer to single question, measured… (low certainty).

1 finding from 1 review

Intervention not reported

Satisfaction with the information provided [single question, measured immediately post‐intervention] · people with a health condition or nominally 'well' considering real or hypothetical clinical trial participation in cancer or psychiatric…

The intervention may leads to higher satisfaction with the information provided [single question,… (low certainty).

1 finding from 1 review

Intervention not reported

Knowledge (Multi‐component intervention) [mean number of correct questionnaire responses, assessed immediately post‐intervention] · People with a health condition or nominally 'well' considering real clinical trial participation (across a range of topic areas)
1 finding from 1 review

Intervention not reported

Rate of participation [case notes, measured immediately post‐intervention] · people with a health condition or nominally 'well' considering real or hypothetical clinical trial participation in cancer or psychiatric…

The intervention showed no clear difference in rate of participation [case notes, measured immediately… (low certainty).

1 finding from 1 review

Intervention not reported

Satisfaction with the decision‐making process (multi‐component intervention) [questionnaire, assessed immediately post‐intervention] · People with a health condition or nominally 'well' considering real clinical trial participation (across a range of topic areas)
1 finding from 1 review

Intervention not reported

Fear of falling3 Immediately post intervention · older people living in the community

The intervention may leads to higher fear of falling3 Immediately post intervention (low certainty).

1 finding from 1 review

Intervention not reported

No or only mild elbow pain Immediate (post aspiration or at an equivalent time) · patients being treated for radial head fractures; subsequent management was non‐surgical

It is very uncertain whether the intervention changes no or only mild elbow pain Immediate (post aspiration or at an… (very low certainty).

1 finding from 1 review

Azoles vs moderate‐potent corticosteroid/azole combinations

Clinical cure · patients with tinea cruris and tinea corporis

It is very uncertain whether azoles changes clinical cure (immediately at end of treatment) Resolution of… compared with moderate‐potent corticosteroid/azole combinations (very low certainty).

1 finding from 1 review

Tizanidine vs carbamazepine

Immediate improvement in pain relief Number of participants improved (good/very good efficacy) on a self assessed categorical 'overall efficacy score' (0 = no efficacy to 4 = very good) · patients with trigeminal neuralgia

Tizanidine showed no clear difference in immediate improvement in pain relief Number of participants improved… compared with carbamazepine (low certainty).

1 finding from 1 review