Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,432 questions · 1,467 findings · 116 reviews · Headline outcomes only

No studies found 232 · 15.8%GRADE not reported 202 · 13.8%Very low 286 · 19.5%Low 327 · 22.3%Moderate 286 · 19.5%High 134 · 9.1%

Thromboelastography (TEG) or thromboelastometry (ROTEM) in combination with SLT or other devices vs clinical judgement or usual care

Proportion of patients receiving FFP · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) in… showed no clear difference in proportion of patients receiving FFP compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) in combination with SLT or other devices vs clinical judgement or usual care

Proportion of patients receiving platelets · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) in… showed no clear difference in proportion of patients receiving platelets compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) in combination with SLT or other devices vs clinical judgement or usual care

Rate of surgical reintervention · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) in… may leads to lower rate of surgical reintervention compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Electrocoagulation in combination with allopurinol or with dimethyl sulphoxide vs control (vehicle solution of allopurinol by mouth)

All‐cause mortality at last · people with liver metastases

Summary of Findings Table ‐ Electrocoagulation in combination with… may leads to lower all‐cause mortality at last compared with control (vehicle solution of allopurinol by mouth) (low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Electrocoagulation in combination with allopurinol or with dimethyl sulphoxide vs control (vehicle solution of allopurinol by mouth)

Post‐operative deaths · people with liver metastases

It is very uncertain whether summary of Findings Table ‐ Electrocoagulation in combination with… changes post‐operative deaths compared with control (vehicle solution of allopurinol by mouth) (very low certainty).

1 finding from 1 review

Intervention not reported

Combination NRT & bupropion versus placebo Smoking cessation · people who have quit smoking using a cessation intervention

The intervention showed no clear difference in combination NRT & bupropion versus placebo Smoking cessation (low certainty).

1 finding from 1 review

Lateral pararectal vs transrectal enterostomy placement

parastomal hernia (RCT) clinical exam, sonography, intraoperatively, or combination, during stoma reversal · people undergoing enterostomy placement for any reason

Lateral pararectal showed no clear difference in parastomal hernia (RCT) clinical exam, sonography, intraoperatively,… compared with transrectal enterostomy placement (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at any gestational age · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at… compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Intervention not reported

Combination of patient mail and telephone reminder or recall · children, adolescents, and adults with a need for routine immunizations, excluding travel immunizations

The intervention probably leads to higher combination of patient mail and telephone reminder or recall (moderate certainty).

1 finding from 1 review

Intervention not reported

Combination of patient reminder or recall with outreach intervention · children, adolescents, and adults with a need for routine immunizations, excluding travel immunizations

The intervention leads to higher combination of patient reminder or recall with outreach intervention (high certainty).

1 finding from 1 review

Intervention not reported

Combination of patient reminder or recall with provider reminder intervention · children, adolescents, and adults with a need for routine immunizations, excluding travel immunizations

The intervention probably leads to higher combination of patient reminder or recall with provider reminder… (moderate certainty).

1 finding from 1 review

Intervention not reported

Knowledge or understanding (Different measures used by the studies: knowledge of vaccine‐preventable diseases, vaccines, contraindications to vaccination, or a combination, on varying scales) Final time point (3 or 6 months post‐intervention) · parents of preschool‐aged children or expectant parents
1 finding from 1 review

Intervention not reported

Attitudes or beliefs (Different measures used by the studies: perceived severity of vaccine‐preventable diseases, perceived necessity of vaccines, or a combination, on varying scales) Final time point (3 or 6 months post‐intervention) · parents of preschool‐aged children or expectant parents
1 finding from 1 review