Cochrane · systematic review · CD013346
Abdominal ultrasound and alpha‐foetoprotein for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease
Colli, A, Nadarevic, T, Miletic, D, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 50%Low 3 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
'Summary of findings' table: diagnostic accuracy of AFP, US, and combination of AFP and US for the diagnosis of HCC
Population: adults with chronic liver disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AFP (cut‐off 20 ng/mL) | no estimate extracted | 147 studies · 52144 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
AFP (cut‐off 200 ng/mL) | no estimate extracted | 56 studies · 20452 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
US | no estimate extracted | 39 studies · 18792 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
Combination of AFP (cut‐off 20 ng/mL) and US | no estimate extracted | 6 studies · 5044 participants | Low Downgraded: risk of bias, inconsistency, indirectness |
'Summary of findings' table: direct comparison of US, and combination of AFP and US
Population: adults with chronic liver disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
US | no estimate extracted | 6 studies · 5044 participants | Low Downgraded: risk of bias, indirectness |
Combination of AFP (cut‐off 20 ng/mL) and US | no estimate extracted | 6 studies · 5044 participants | Low Downgraded: risk of bias, indirectness |