Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

948 questions · 998 findings · 100 reviews · Headline outcomes only

No studies found 233 · 23.3%GRADE not reported 40 · 4%Very low 203 · 20.3%Low 271 · 27.2%Moderate 176 · 17.6%High 75 · 7.5%

Vitamin D given to infants vs vitamin D given to lactating mothers

Hypercalcaemia · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to infants showed no clear difference in adverse effect (hypercalcaemia) compared with vitamin D given to lactating mothers (low certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Persons with hypercalcaemia ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium showed no clear difference in persons with hypercalcaemia ‐ Vitamin D (D2, D3 or 25(OH)D) plus… compared with control or placebo (low certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Persons with renal disease (calculi or insufficiency) ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to higher persons with renal disease (calculi or insufficiency) ‐ Vitamin D… compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium showed no clear difference in deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review