Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

191 questions · 196 findings · 20 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 65 · 33.2%GRADE not reported 9 · 4.6%Very low 26 · 13.3%Low 46 · 23.5%Moderate 36 · 18.4%High 14 · 7.1%

Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo

Number experiencing adverse effects · children with cystic fibrosis and a new culture positive for P aeruginosa

Inhaled tobramycin (TNS) plus oral azithromycin showed no clear difference in adverse effects of antibiotics: number of participants experiencing… compared with TNS plus oral placebo (moderate certainty).

1 finding from 1 review