Question · asked by 1 review
Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo: Number experiencing adverse effects
- Population
- children with cystic fibrosis and a new culture positive for P aeruginosa
- Intervention
- Inhaled tobramycin (TNS) plus oral azithromycin
- Comparison
- TNS plus oral placebo
- Outcome
- Number experiencing adverse effects
Inhaled tobramycin (TNS) plus oral azithromycin showed no clear difference in adverse effects of antibiotics: number of participants experiencing… compared with TNS plus oral placebo (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo Adverse effects of antibiotics: number of participants experiencing any adverse event · children with cystic fibrosis and a new culture positive for P aeruginosa Inhaled tobramycin (TNS) plus oral azithromycin showed no clear difference in adverse effects of antibiotics: number of participants experiencing… compared with TNS plus oral placebo (moderate certainty). Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane Headline outcomes only | RR 1.05 [0.96, 1.14] | 1 study · 221 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.