Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

87 questions · 95 findings · 18 reviews · Anaesthesia

No studies found 5 · 5.3%GRADE not reported 2 · 2.1%Very low 28 · 29.5%Low 39 · 41.1%Moderate 21 · 22.1%High 0 · 0%

Epidural analgesia vs intravenous patient‐controlled analgesia

All‐cause mortality rate at 30 days · adults having abdominal surgery

Epidural analgesia showed no clear difference in all‐cause mortality rate at 30 days compared with intravenous patient‐controlled analgesia (low certainty).

1 finding from 1 review

Epidural analgesia vs intravenous patient‐controlled analgesia

Failure of analgesic technique requiring alternative approach (assessed at any time) · adults having abdominal surgery

Epidural analgesia probably leads to higher failure of analgesic technique requiring alternative approach… compared with intravenous patient‐controlled analgesia (moderate certainty).

1 finding from 1 review

Epidural analgesia vs intravenous patient‐controlled analgesia

Adverse events (assessed at any time during · adults having abdominal surgery

Epidural analgesia showed no clear difference in adverse events (assessed at any time during compared with intravenous patient‐controlled analgesia (low certainty).

1 finding from 1 review

Inhalational anaesthesia vs intravenous anaesthesia

Nausea · adults undergoing transabdominal robotic assisted laparoscopic surgery

Inhalational anaesthesia may leads to lower presence of nausea compared with intravenous anaesthesia (low certainty).

3 findings from 1 review

Inhalational anaesthesia vs intravenous anaesthesia

Nausea and vomiting · adults undergoing transabdominal robotic assisted laparoscopic surgery

It is very uncertain whether inhalational anaesthesia changes nausea‐vomiting rate at 1 hour compared with intravenous anaesthesia (very low certainty).

2 findings from 1 review

Maintenance anaesthesia: inhalational vs intravenous

Nausea and vomiting ‐ subgroup analysis: thiopentone or halothane + N2O versus propofol or propofol + N2O · paediatric

Maintenance anaesthesia: inhalational may leads to higher nausea and vomiting ‐ subgroup analysis: thiopentone or halothane +… compared with intravenous (low certainty).

2 findings from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Major complications · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes major complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Mortality within the longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes all‐cause mortality (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Length of hospital stay · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes length of hospital stay (days) compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Surgery‐related complications (during longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Non‐surgery‐related complications (during longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes non‐surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review