Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

231 questions · 236 findings · 32 reviews · Gynaecology and Fertility

No studies found 31 · 13.1%GRADE not reported 5 · 2.1%Very low 74 · 31.4%Low 91 · 38.6%Moderate 35 · 14.8%High 0 · 0%

Any glucocorticoid vs no glucocorticoids or placebo

Clinical pregnancy rate per couple – subgroup IVF · assisted reproduction technology cycles

It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple – subgroup IVF compared with no glucocorticoids or placebo (very low certainty).

1 finding from 1 review

G‐CSF vs no treatment or placebo

Clinical pregnancy rate ‐ unselected or unstated IVF number · Subfertile women undergoing assisted reproduction

G‐CSF showed no clear difference in clinical pregnancy rate ‐ unselected or unstated IVF number compared with no treatment or placebo (low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ G2 (specific) versus Universal IVF (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ G2 (specific) versus Universal IVF (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer: Cook (K‐SIFM or K‐SICM) (specific) versus Vitrolife (IVF or G3) (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

The intervention showed no clear difference in early embryo transfer: Cook (K‐SIFM or K‐SICM) (specific) versus… (low certainty).

1 finding from 1 review

Intervention not reported

Late embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes late embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Late embryo transfer ‐ G2 (specific) versus Universal IVF (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes late embryo transfer ‐ G2 (specific) versus Universal IVF (other) (very low certainty).

1 finding from 1 review

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

Live birth · Women undergoing ART (IVF, ICSI, or frozen embryo transfer)

ART with seminal plasma showed no clear difference in live birth compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

1 finding from 1 review

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

Miscarriage · Women undergoing ART (IVF, ICSI, or frozen embryo transfer)

ART with seminal plasma showed no clear difference in miscarriage compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

1 finding from 1 review

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

Live birth or ongoing pregnancy · Women undergoing ART (IVF, ICSI, or frozen embryo transfer)

ART with seminal plasma showed no clear difference in live birth or ongoing pregnancy compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

1 finding from 1 review

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

Clinical pregnancy · Women undergoing ART (IVF, ICSI, or frozen embryo transfer)

It is very uncertain whether ART with seminal plasma changes clinical pregnancy compared with standard ART (IVF, ICSI, and frozen embryo transfer) (very low certainty).

1 finding from 1 review

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

Multiple pregnancy · Women undergoing ART (IVF, ICSI, or frozen embryo transfer)

ART with seminal plasma showed no clear difference in multiple pregnancy compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

1 finding from 1 review

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

Ectopic pregnancy · Women undergoing ART (IVF, ICSI, or frozen embryo transfer)

It is very uncertain whether ART with seminal plasma changes ectopic pregnancy compared with standard ART (IVF, ICSI, and frozen embryo transfer) (very low certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Live birth rate per woman · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

It is very uncertain whether day 3 changes live birth rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

1 finding from 1 review