Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

70 questions · 75 findings · 11 reviews · Pain, Palliative and Supportive Care

No studies found 14 · 18.7%GRADE not reported 1 · 1.3%Very low 35 · 46.7%Low 18 · 24%Moderate 4 · 5.3%High 3 · 4%

Intravenous diclofenac vs placebo

Number of participants experiencing any serious adverse events · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac showed no clear difference in number of participants experiencing a serious adverse event compared with placebo (low certainty).

1 finding from 1 review

Intravenous diclofenac vs NSAIDs

At least 50% reduction in pain · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries
2 findings from 1 review

Intervention not reported

Participants with at least 30% or at least 50% reduction in pain · people with cancer pain
1 finding from 1 review

Intervention not reported

PGIC much or very much improved · people with cancer pain
1 finding from 1 review

Intervention not reported

Mean pain intensity at end of study · people with cancer pain
1 finding from 1 review

Intervention not reported

Pain no worse than mild at one or two weeks (or equivalent) · people with cancer pain
1 finding from 1 review

Intervention not reported

Mean quality of life or "well‐being" · people with cancer pain
1 finding from 1 review

Intervention not reported

Participant preference · people with cancer pain
1 finding from 1 review

Intervention not reported

Serious adverse events · people with cancer pain
1 finding from 1 review

Paracetamol 500 mg to 650 mg vs placebo

Pain‐free at 1 hour · adults with episodic tension‐type headache

The review found no eligible studies for this question.

2 findings from 1 review