Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

445 questions · 449 findings · 45 reviews · Airways

No studies found 35 · 7.8%GRADE not reported 26 · 5.8%Very low 30 · 6.7%Low 134 · 29.8%Moderate 160 · 35.6%High 64 · 14.3%

Increased vs stable doses of inhaled corticosteroids

Treatment failure ‐ need for systemic corticosteroids (ITT) · adults and children with chronic asthma

Increased showed no clear difference in treatment failure: need for systemic corticosteroids (ITT) compared with stable doses of inhaled corticosteroids (moderate certainty).

1 finding from 1 review

Increased vs stable doses of inhaled corticosteroids

Treatment failure ‐ need for systemic corticosteroids (of those starting inhaler) · adults and children with chronic asthma

It is very uncertain whether increased changes treatment failure: need for systemic corticosteroids (of those… compared with stable doses of inhaled corticosteroids (very low certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

All‐cause mortality · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care showed no clear difference in all‐cause mortality compared with standard care (with or without placebo) (low certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Admission to hospital or death · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care probably leads to lower admission to hospital or death compared with standard care (with or without placebo) (moderate certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Resolution of symptoms · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care probably leads to higher symptom resolution: all initial symptoms resolved at day 14 compared with standard care (with or without placebo) (moderate certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Time to symptom resolution · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care showed no clear difference in symptom resolution: duration to symptoms resolved compared with standard care (with or without placebo) (low certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Serious adverse events · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

It is very uncertain whether inhaled corticosteroids plus standard care changes serious adverse events compared with standard care (with or without placebo) (very low certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Adverse events · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care showed no clear difference in adverse events compared with standard care (with or without placebo) (low certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Infections · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care showed no clear difference in infections compared with standard care (with or without placebo) (low certainty).

1 finding from 1 review

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs beclomethasone

Linear growth velocity (cm/year) · children up to 18 years of age with persistent asthma

Effects of different inhaled corticosteroids on growth in children… may leads to higher linear growth velocity (cm/year) compared with beclomethasone (low certainty).

1 finding from 1 review

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs budesonide

Linear growth velocity (cm/year) · children up to 18 years of age with persistent asthma

It is very uncertain whether effects of different inhaled corticosteroids on growth in children… changes linear growth velocity (cm/year) compared with budesonide (very low certainty).

1 finding from 1 review