Cochrane · systematic review · CD009305
Inhaled corticosteroids for subacute and chronic cough in adults
Johnstone, KJ, Chang, AB, Fong, KM, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Inhaled corticosteroids (ICS) compared to placebo for adults with subacute and chronic cough
Population: adults with subacute and chronic cough
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Primary outcome Inhaled corticosteroids (ICS) vs placebo | no estimate extracted | NR | No studies |
Proportion of participants who achieved clinical cure or significant improvement (> 70% reduction in cough severity measure) at Inhaled corticosteroids (ICS) vs placebo | no estimate extracted | 3 studies · 180 participants | Low Downgraded: risk of bias |
Secondary outcomes Inhaled corticosteroids (ICS) vs placebo | no estimate extracted | NR | No studies |
Proportion of participants who achieved clinical cure or > 50% reduction in cough severity measure at Inhaled corticosteroids (ICS) vs placebo | no estimate extracted | 4 studies · 230 participants | Low Downgraded: risk of bias |
Proportion of participants with clinical cure at Inhaled corticosteroids (ICS) vs placebo | no estimate extracted | 4 studies · 320 participants | Low Downgraded: risk of bias |
Mean change in cough score Symptomatic cough severity measure as assessed by the patient Inhaled corticosteroids (ICS) vs placebo | no estimate extracted | 5 studies · 346 participants | Low Downgraded: risk of bias |
Proportion with adverse effects of treatment Inhaled corticosteroids (ICS) vs placebo | OR 1.67 [0.92, 3.04] | 4 studies · 381 participants | Moderate Downgraded: risk of bias |