Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

78 questions · 78 findings · 9 reviews · Neonatal

No studies found 19 · 24.4%GRADE not reported 5 · 6.4%Very low 16 · 20.5%Low 21 · 26.9%Moderate 17 · 21.8%High 0 · 0%

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Bronchopulmonary dysplasia · preterm infants receiving nasal CPAP

Bubble showed no clear difference in bronchopulmonary dysplasia compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).

1 finding from 1 review

Early vs late continuous positive airway pressure (CPAP)

Use of IPPV before discharge · preterm infants with respiratory distress for initial respiratory support

It is very uncertain whether early changes use of IPPV before discharge compared with late continuous positive airway pressure (CPAP) (very low certainty).

1 finding from 1 review

Early vs late continuous positive airway pressure (CPAP)

Pulmonary air leak defined as pneumothorax · preterm infants with respiratory distress for initial respiratory support

Early showed no clear difference in air leak (pneumothorax) compared with late continuous positive airway pressure (CPAP) (low certainty).

1 finding from 1 review

Early vs late continuous positive airway pressure (CPAP)

Bronchopulmonary dysplasia at 36 weeks' postmenstrual age · preterm infants with respiratory distress for initial respiratory support

It is very uncertain whether early changes bronchopulmonary dysplasia at 36 weeks' postmenstrual age compared with late continuous positive airway pressure (CPAP) (very low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs supplemental oxygen

Treatment failure (death or use of additional ventilatory support) · preterm infants with respiratory distress for initial respiratory support

It is very uncertain whether CPAP changes treatment failure (death or use of additional ventilatory support) compared with supplemental oxygen (very low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs supplemental oxygen

Bronchopulmonary dysplasia at 28 days · preterm infants with respiratory distress for initial respiratory support

It is very uncertain whether CPAP changes bronchopulmonary dysplasia (oxygen dependency at 28 days) compared with supplemental oxygen (very low certainty).

1 finding from 1 review