Cochrane · systematic review · CD013660
Continuous positive airway pressure (CPAP) for apnoea of prematurity
Ho, JJ, Zakarija-Grkovic, I, Lok, JW, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
3
No studies
10
Included studies
NR
No studies 10 · 66.7%Ungraded 2 · 13.3%Very low 3 · 20%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
CPAP and supportive care compared to supportive care for apnoea of prematurity
Population: preterm infants with apnoea of prematurity
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failed CPAP CPAP and supportive care vs supportive care | no estimate extracted | NR | No studies |
Mean apnoea events CPAP and supportive care vs supportive care | no estimate extracted | NR | No studies |
Adverse events CPAP and supportive care vs supportive care | no estimate extracted | NR | No studies |
Long‐term neurodevelopmental outcomes CPAP and supportive care vs supportive care | no estimate extracted | NR | No studies |
Variable flow compared to ventilator CPAP for apnoea of prematurity
Population: preterm infants with apnoea of prematurity (median age 9 days)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failed CPAP (defined as need for mechanical ventilation) Variable flow vs ventilator CPAP | RR 0.16 [0.01, 2.9] | 1 study · 26 participants | Very low Downgraded: risk of bias |
Mean apnoea events (apnoea > 20 seconds with or without bradycardia or desaturation) Mean per 4‐hour interval Variable flow vs ventilator CPAP | no estimate extracted | 1 study · 26 participants | Very low Downgraded: risk of bias |
Long‐term neurodevelopmental outcomes Variable flow vs ventilator CPAP | no estimate extracted | NR | No studies |
Variable flow compared to bubble CPAP for apnoea of prematurity
Population: preterm infants, 24 to 29 weeks gestation and mean age 18 days with apnoea of prematurity
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failed CPAP Variable flow vs bubble CPAP | no estimate extracted | NR | No studies |
Mean apnoea events Variable flow vs bubble CPAP | no estimate extracted | NR | No studies |
Adverse events Variable flow vs bubble CPAP | no estimate extracted | NR | No studies |
Long‐term neurodevelopmental outcomes Variable flow vs bubble CPAP | no estimate extracted | NR | No studies |
Infant Flow CPAP compared to Medijet CPAP for apnoea of prematurity
Population: preterm infants with apnoea of prematurity (gestation 27 weeks, age not stated)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failed CPAP Infant Flow CPAP vs Medijet CPAP | RR 2.62 [0.91, 7.53] | 1 study · 80 participants | Very low Downgraded: risk of bias |
Mean apnoea events Infant Flow CPAP vs Medijet CPAP | no estimate extracted | 24 participants | Ungraded |
Adverse events Infant Flow CPAP vs Medijet CPAP | 2 | 2 participants | Ungraded |
Long‐term neurodevelopmental outcomes Infant Flow CPAP vs Medijet CPAP | no estimate extracted | NR | No studies |