Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Continuation vs discontinuation of antiplatelet therapy

Blood loss requiring further surgery (intraoperatively and postoperatively) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in blood loss requiring further surgery (intraoperatively and… compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Ischaemic events: peripheral thrombosis, cerebral myocardial infarction (within 30 days of surgery) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in ischaemic events: peripheral thrombosis, cerebral myocardial… compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Intervention not reported

ILAE Epilepsy Surgery Outcome · patients undergoing epilepsy surgery with medically refractory epilepsy

The review found no eligible studies for this question.

1 finding from 1 review

Remote ischaemic preconditioning (RIPC) vs no RIPC

Composite endpoint (including all‐cause mortality, non‐fatal myocardial infarction and/or any new stroke assessed at 30 days after surgery) · people undergoing CABG (with or without valve surgery)

RIPC showed no clear difference in composite endpoint (including all‐cause mortality, non‐fatal… compared with no RIPC (moderate certainty).

1 finding from 1 review

NSAIDS plus steroids vs steroids

Poor vision due to MO at 12 months after surgery · patients undergoing cataract surgery

It is very uncertain whether NSAIDS plus steroids changes poor vision due to MO at 12 months after surgery compared with steroids (very low certainty).

1 finding from 1 review