It is very uncertain whether IM pethidine changes maternal satisfaction with analgesia measured during labour (number… compared with placebo (very low certainty).
IM pethidine may leads to higher maternal pain score or pain measured in labour (described as good or… compared with placebo (low certainty).
IM pethidine may leads to higher maternal pain score or pain measured in labour (reduction in VAS of… compared with placebo (low certainty).
IM pethidine may leads to lower additional analgesia required (epidural, pethidine and Entonox) compared with placebo (low certainty).
It is very uncertain whether IM pethidine changes epidural compared with placebo (very low certainty).
Metformin showed no clear difference in large‐for‐gestational‐age infant, defined as birthweight ≥ 90th… compared with placebo (high certainty).
Metformin showed no clear difference in gestational hypertension compared with placebo (low certainty).
Metformin showed no clear difference in pre‐eclampsia compared with placebo (low certainty).
Metformin showed no clear difference in gestational diabetes (as defined by the trial authors) compared with placebo (moderate certainty).
Metformin leads to higher adverse effects associated with the treatment: diarrhoea compared with placebo (high certainty).
Standard care plus IV tranexamic acid showed no clear difference in maternal mortality due to bleeding compared with placebo or standard care alone (moderate certainty).
Standard care plus IV tranexamic acid showed no clear difference in maternal mortality (all causes) compared with placebo or standard care alone (moderate certainty).
Standard care plus IV tranexamic acid showed no clear difference in serious maternal morbidity (any) compared with placebo or standard care alone (high certainty).
Standard care plus IV tranexamic acid may leads to lower blood loss 500 mL or more after randomisation compared with placebo or standard care alone (low certainty).
Standard care plus IV tranexamic acid showed no clear difference in blood transfusion (any) compared with placebo or standard care alone (moderate certainty).
Standard care plus IV tranexamic acid showed no clear difference in surgical intervention to control bleeding: Hysterectomy compared with placebo or standard care alone (high certainty).
Standard care plus IV tranexamic acid showed no clear difference in side effects of the intervention: Any maternal vascular occlusive… compared with placebo or standard care alone (moderate certainty).