Question · asked by 1 review
Metformin vs placebo: Pre‐eclampsia
- Population
- women with obesity during pregnancy
- Intervention
- Metformin
- Comparison
- placebo
- Outcome
- Pre‐eclampsia
Metformin showed no clear difference in pre‐eclampsia compared with placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Metformin vs placebo Pre‐eclampsia · women with obesity during pregnancy Metformin showed no clear difference in pre‐eclampsia compared with placebo (low certainty). Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes (2018) · Cochrane Headline outcomes only | RR 0.74 [0.09, 6.28] | 2 studies · 840 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes 2018 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.