Cochrane · systematic review · CD010564
Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes
Dodd, JM, Grivell, RM, Deussen, AR, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 1 · 14.3%High 3 · 42.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Metformin compared to placebo for women with obesity during pregnancy
Population: women with obesity during pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Large‐for‐gestational‐age infant, defined as birthweight ≥ 90th percentile for gestational age and infant sex Metformin vs placebo | RR 0.95 [0.7, 1.3] | 2 studies · 831 participants | High |
Gestational weight gain (kg) Metformin vs placebo | no estimate extracted | 3 studies · 899 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Gestational hypertension Metformin vs placebo | RR 1.02 [0.54, 1.94] | 3 studies · 1040 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Pre‐eclampsia Metformin vs placebo | RR 0.74 [0.09, 6.28] | 2 studies · 840 participants | Low Downgraded: imprecision, inconsistency |
Gestational diabetes (as defined by the trial authors) Metformin vs placebo | RR 0.85 [0.61, 1.19] | 3 studies · 892 participants | Moderate Downgraded: risk of bias, imprecision |
Adverse effects associated with the treatment: diarrhoea Metformin vs placebo | RR 2.34 [1.74, 3.14] | 2 studies · 797 participants | High |
Birthweight (g) Metformin vs placebo | no estimate extracted | 2 studies · 834 participants | High |