Dental caries · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK Biobank European…
Meta-analysis identified a novel genome-wide-significant locus for dental caries at rs4801882 in SIGLEC5 (P=1.71E-08); ungraded.
1 finding from 1 review
Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) · Adolescents (10-19 years)
Malocclusion (DAI) probably increases the prevalence of impaired OHRQoL (CPQ 11-14) by about 15% in adolescents (RR/PR 1.15, 95% CI 1.12-1.18; moderate certainty).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · People or specimens with white spot lesions or early caries lesions
The NMA estimated an SMD of -0.78 for P11-4 + fluoride varnish versus CPP-ACP (95% CI -1.33 to -0.28).
1 finding from 1 review
SMD -0.78 [-1.33, -0.24]
Studies not reported
GRADE not reported
Intervention not reported
7‐methylxanthine · children with progressive myopia (36 studies, 6263 participants) in the analysis Interventions: optical and pharmacological Comparator:…
1 finding from 1 review
Intervention not reported
7‐methyxanthine · children with progressive myopia (38 studies, 6525 participants in analyses) Interventions: optical and pharmacological Comparator:…
1 finding from 1 review
Endometrial histology · young women with Turner syndrome who have completed pubertal induction
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Endometrial thickness (mm) · women with premature ovarian insufficiency (POI) awaiting oocyte donation
2 findings from 1 review
Endometrial histology · women with premature ovarian insufficiency (POI) awaiting oocyte donation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Endometrial thickness (mm) · girls with Turner syndrome who were treated with prepubertal growth hormone
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Endometrial histology · girls with Turner syndrome who were treated with prepubertal growth hormone
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Endometrial thickness (mm) · young women with Turner syndrome who have completed pubertal induction
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proportion of participants with confirmed macular edema (lower number of events is better) · NIIPPU
It is very uncertain whether methotrexate changes proportion of participants with confirmed macular edema (lower… compared with mycophenolate (very low certainty).
1 finding from 1 review
Proportion of participants achieving steroid‐sparing control (higher number of events is better) · NIIPPU
Methotrexate probably leads to higher proportion of participants achieving steroid‐sparing control§… compared with mycophenolate (moderate certainty).
1 finding from 1 review
Proportion of participants experiencing complications or requiring cessation of medication (lower number of events is better) · NIIPPU
Methotrexate showed no clear difference in proportion of participants experiencing complications or requiring… compared with mycophenolate (low certainty).
1 finding from 1 review
Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU
Methotrexate probably leads to higher proportion of participants achieving control of inflammation§… compared with mycophenolate (moderate certainty).
1 finding from 1 review
Change in BCVA (lower logMAR indicate better vision) · NIIPPU
1 finding from 1 review
Proportion of participants achieving a 2‐line improvement in visual acuity (Snellen chart) (higher scores indicate better vision) · NIIPPU
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Functional status ‐ 6MWD (metres) · COPD and at least one other long‐term condition
1 finding from 1 review
Functional status ‐ 6MWD (metres) · COPD and at least one other long‐term condition
1 finding from 1 review
Endometrial thickness (mm) · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes
1 finding from 1 review