Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,741 questions · 1,821 findings · 207 reviews

No studies found 297 · 16.3%GRADE not reported 191 · 10.5%Very low 333 · 18.3%Low 466 · 25.6%Moderate 414 · 22.7%High 120 · 6.6%

Valproate vs lithium

Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in individual adverse events ‐ Sedation At 3 weeks (secondary… compared with lithium (low certainty).

1 finding from 1 review

Valproate vs lithium

Adverse events: somnolence/sedation · Children and adolescents with acute mania

It is very uncertain whether valproate changes individual adverse events ‐ Sedation At 8 weeks (secondary… compared with lithium (very low certainty).

1 finding from 1 review

Valproate vs placebo

Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in individual adverse events ‐ Sedation At 3‐8 weeks (secondary… compared with placebo (high certainty).

1 finding from 1 review

Valproate vs placebo

Adverse effects: 1. Sedation · Children and adolescents with acute mania

It is very uncertain whether valproate changes individual adverse events ‐ Sedation At 4 weeks (secondary… compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Pregnancy with serious adverse outcome (composite including maternal death, baby death, pre‐eclampsia, small‐for‐gestational age, preterm birth) ‐ only trials with individual participant data · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower pregnancy with serious adverse outcome (composite including maternal… (high certainty).

1 finding from 1 review

Early enteral nutrition vs delayed enteral nutrition

Feed intolerance or gastrointestinal complications (as defined by the authors) · critically ill adult patients

It is very uncertain whether early enteral nutrition changes feed intolerance or gastrointestinal complications (as defined by… compared with delayed enteral nutrition (very low certainty).

1 finding from 1 review