Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,320 questions · 4,561 findings · 388 reviews

No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

Vi polysaccharide vaccine (1 dose) vs control

Cumulative cases of typhoid fever at 2.5 to 3 years · adults and children of 2 years of age and older

Vi polysaccharide vaccine (1 dose) may leads to lower cumulative cases of typhoid fever at 2.5 to 3 years compared with control (low certainty).

1 finding from 1 review

Medication reconciliation interventions vs usual care

Hospital usage (composite measure of ED, rehospitalisation) · all patients (aged > 18 years) at a transition of care

It is very uncertain whether medication reconciliation interventions changes hospital usage (composite measure of ED, rehospitalisation) compared with standard care (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events Measured by: proportion of serious adverse events (total) Average study duration (range): not stated · children and adolescents aged 18 years and under diagnosed with ADHD

It is very uncertain whether the intervention changes serious adverse events Measured by: proportion of serious adverse… (very low certainty).

1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to serious adverse events (non‐comparative cohort studies) Measured by: proportion of participants withdrawn from treatment Average study duration (range): 7.9 months (1 month to 37 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to adverse events of unknown severity Measured by: proportion of participants withdrawn from treatment Average study duration (range): 4.6 months (21 days to 36 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to non‐serious adverse events Measured by: proportion of participants withdrawn from treatment Average study duration (range): 5.60 months (0.6 months to 41 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate for unknown reasons Measure by: proportion of participants withdrawn from treatment Average study duration (range): 6.13 months (1 day to 36 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Child death by two years of age · HIV‐positive women during pregnancy and immediate postpartum period

The intervention showed no clear difference in child death by two years of age (low certainty).

1 finding from 1 review

Capnography and standard monitoring vs standard monitoring

Airway interventions adult subgroup analysis (aged ≥ 18 years)h · patients undergoing PSA

Capnography and standard monitoring probably leads to higher airway interventions adult subgroup analysis (aged ≥ 18 years)h compared with standard monitoring (moderate certainty).

1 finding from 1 review

Motivational interview plus oral health education vs Oral health education

Self regulation: Average score (Treatment Self Regulation Questionnaire, high score = good) · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

Motivational interview plus oral health education showed no clear difference in self regulation: Average score (Treatment Self Regulation… compared with oral health education; GRADE not reported.

3 findings from 1 review

Motivational interview plus oral health education vs Oral health education

Oral health knowledge (1-9 scale) · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

Motivational interview plus oral health education led to higher knowledge: Average score (Oral Health Knowledge Questionnaire, high… compared with oral health education; GRADE not reported.

1 finding from 1 review

Anterior prolapse repair: native tissue vs absorbable mesh

Repeat surgery for prolapse (stage 2 or greater) at 2 years · women with anterior compartment pelvic organ prolapse

It is very uncertain whether anterior prolapse repair: native tissue changes repeat surgery for prolapse (stage 2 or greater) at 2 years compared with absorbable mesh (very low certainty).

1 finding from 1 review