Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,703 questions · 15,007 findings · 1,416 reviews

No studies found 2,881 · 19.2%GRADE not reported 1,551 · 10.3%Very low 3,111 · 20.7%Low 3,881 · 25.9%Moderate 2,669 · 17.8%High 914 · 6.1%

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Antibiotics vs placebo or no intervention

Sudden cardiac death · patients with coronary heart disease

Antibiotics probably leads to higher sudden cardiac death at 24±6 months compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Cilostazol vs placebo

Arterial revascularisation · intermittent claudication

It is very uncertain whether cilostazol changes arterial revascularisation (number of cases) compared with placebo (very low certainty).

1 finding from 1 review

Cilostazol vs placebo

Amputation · intermittent claudication

It is very uncertain whether cilostazol changes amputation (number of cases) compared with placebo (very low certainty).

1 finding from 1 review

Cilostazol vs placebo

Adverse event related to study medication ‐ headache (number of cases) · intermittent claudication

Cilostazol probably leads to higher adverse event related to study medication ‐ headache (number of cases) compared with placebo (moderate certainty).

1 finding from 1 review

Cilostazol vs placebo

Cardiovascular events · intermittent claudication

Cilostazol showed no clear difference in cardiovascular event (number of cases) compared with placebo (low certainty).

1 finding from 1 review

Antihypertensive drug therapy vs placebo

Number of cases of dementia Range of · participants without prior cerebrovascular disease for prevention of cognitive impairment and dementia

It is very uncertain whether antihypertensive therapy changes number of cases of dementia Range of compared with placebo (very low certainty).

1 finding from 1 review

Antidepressants vs placebo

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant changes clinical response of depression compared with placebo (very low certainty).

1 finding from 1 review