Antibiotics vs placebo or no intervention: Sudden cardiac death
Antibiotics probably leads to higher sudden cardiac death at 24±6 months compared with placebo or no intervention (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antibiotics vs placebo or no intervention Sudden cardiac death at 24±6 months · patients with coronary heart disease Antibiotics probably leads to higher sudden cardiac death at 24±6 months compared with placebo or no intervention (moderate certainty). Antibiotics for secondary prevention of coronary heart disease (2021) · Cochrane Headline outcomes only | RR 1.77 [1.28, 2.44] | 2 studies · 4520 participants | Moderate |
Antibiotics vs placebo or no intervention Sudden cardiac death at maximum · patients with coronary heart disease Antibiotics showed no clear difference in sudden cardiac death at maximum compared with placebo or no intervention (moderate certainty). Antibiotics for secondary prevention of coronary heart disease (2021) · Cochrane Headline outcomes only | RR 1.08 [0.9, 1.31] | 2 studies · 4520 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antibiotics for secondary prevention of coronary heart disease 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.