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Evidence found and GRADE certainty

3,535 questions · 3,601 findings · 252 reviews · Pregnancy and Childbirth

No studies found 726 · 20.2%GRADE not reported 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Chlorhexidine vaginal wash vs placebo

Chorioamnionitis Clinical findings · Pregnant women with a gestational age greater than 28 weeks, considered to be in labour receiving chlorhexidine vaginal douching during…

Chlorhexidine vaginal wash showed no clear difference in chorioamnionitis Clinical findings compared with placebo (moderate certainty).

1 finding from 1 review

Chlorhexidine vaginal wash vs placebo

Postpartum endometritis Clinical findings · Pregnant women with a gestational age greater than 28 weeks, considered to be in labour receiving chlorhexidine vaginal douching during…

Chlorhexidine vaginal wash showed no clear difference in postpartum endometritis Clinical findings compared with placebo (moderate certainty).

1 finding from 1 review

Chlorhexidine vaginal wash vs placebo

Neonatal sepsis · Pregnant women with a gestational age greater than 28 weeks, considered to be in labour receiving chlorhexidine vaginal douching during…

Chlorhexidine vaginal wash showed no clear difference in neonatal sepsis Clinical findings compared with placebo (low certainty).

1 finding from 1 review

Chlorhexidine vaginal wash vs placebo

Blood culture confirming neonatal sepsis Clinical findings and confirmation by laboratory · Pregnant women with a gestational age greater than 28 weeks, considered to be in labour receiving chlorhexidine vaginal douching during…

Chlorhexidine vaginal wash showed no clear difference in blood culture confirming neonatal sepsis Clinical findings and… compared with placebo (low certainty).

1 finding from 1 review

Antibiotic prophylaxis vs no treatment

Infection rate at 2 weeks postpartum ‐ perineal wound infection in third‐ or fourth‐degree tear · Women with third‐ and fourth‐degree perineal tear during vaginal birth

Antibiotic prophylaxis probably leads to lower infection rate at 2 weeks postpartum ‐ perineal wound infection in… compared with no treatment (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis vs no treatment

Infection rate at 6 weeks postpartum ‐ perineal wound infection in third‐ or fourth‐degree tear · Women with third‐ and fourth‐degree perineal tear during vaginal birth

Antibiotic prophylaxis showed no clear difference in infection rate at 6 weeks postpartum ‐ perineal wound infection in… compared with no treatment (low certainty).

1 finding from 1 review

Early initiation of epidural analgesia vs Late initiation

Caesarean section · pregnant women (at term) requesting epidural analgesia in labour (regardless of whether the labour was spontaneous or induced)

Early initiation of epidural analgesia showed no clear difference in caesarean section compared with late initiation (high certainty).

1 finding from 1 review

Early initiation of epidural analgesia vs Late initiation

Instrumental delivery · pregnant women (at term) requesting epidural analgesia in labour (regardless of whether the labour was spontaneous or induced)

Early initiation of epidural analgesia showed no clear difference in instrumental delivery compared with late initiation (high certainty).

1 finding from 1 review

Early initiation of epidural analgesia vs Late initiation

Apgar score less than 7 at 5 minutes · pregnant women (at term) requesting epidural analgesia in labour (regardless of whether the labour was spontaneous or induced)

Early initiation of epidural analgesia showed no clear difference in apgar score <7 at 5 min compared with late initiation (high certainty).

1 finding from 1 review

Lanolin vs expressed breast milk

Nipple pain Women's reports of 'absence of irritation' · breastfeeding women with sore nipples

Lanolin showed no clear difference in nipple pain Women's reports of 'absence of irritation' compared with expressed breast milk (low certainty).

3 findings from 1 review