Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

929 questions · 946 findings · 295 reviews · Headline outcomes only

No studies found 150 · 15.9%GRADE not reported 47 · 5%Very low 312 · 33%Low 262 · 27.7%Moderate 138 · 14.6%High 37 · 3.9%

Eculizumab vs placebo

Participants with 1 or more serious adverse events · adults with severe Guillain‐Barré syndrome (GBS disability score > 2), within 2 weeks form onset

Eculizumab showed no clear difference in participants with 1 or more serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Interferon beta‐1a vs placebo

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether interferon beta‐1a changes participants with 1 or more serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

CBT vs no treatment or treatment

Victim empathy: attitudes to women Measured by: Attitude Towards Women Scale (15 items; scores range from 0 to 45; higher scores indicate more egalitarian attitudes towards women) · young people (aged 10 to 18 years old) with harmful sexual behaviour
1 finding from 1 review

Nicotine replacement therapy vs control

Biochemically validated smoking cessation at the latest point in pregnancy (20 weeks' gestation or more) · Pregnant women who smoke

Nicotine replacement therapy may leads to higher biochemically validated smoking cessation at the latest point in… compared with control (low certainty).

1 finding from 1 review

Bupropion vs control

Biochemically validated smoking cessation at the latest point in pregnancy (20 weeks' gestation or more) · Pregnant women who smoke

Bupropion showed no clear difference in biochemically validated smoking cessation at the latest point in… compared with control (low certainty).

1 finding from 1 review

Procedures: donning and doffing with instructions vs No special instructions (control)

People with one or more errors · healthcare workers

It is very uncertain whether procedures: donning and doffing with instructions changes people with one or more errors compared with without instruction (very low certainty).

1 finding from 1 review

Wavefront‐guided LASIK vs wavefront‐guided PRK

Loss of 1 or more lines of BSCVA at 12 months post treatment · Adults with refractive errors

It is very uncertain whether wavefront‐guided LASIK changes proportion of eyes that had lost 1 or more lines of best… compared with wavefront‐guided PRK (very low certainty).

1 finding from 1 review

Wavefront procedures vs conventional procedures

Proportion of eyes that had lost 1 or more lines of best spectacle‐corrected visual acuity (BSCVA) posttreatment:12 months ‐ Procedure PRK · Adults with refractive errors

Wavefront procedures showed no clear difference in proportion of eyes that had lost 1 or more lines of best… compared with conventional procedures (low certainty).

1 finding from 1 review

Wavefront procedures vs conventional procedures

Proportion of eyes that had lost 1 or more lines of best spectacle‐corrected visual acuity (BSCVA) posttreatment‐procedure LASIK; Mean higher‐order aberrations (HOAs) post‐treatment, measured by machine with wavefront sensor; proportion of eyes wi... · Adults with refractive errors

The review found no eligible studies for this question.

1 finding from 1 review

Wavefront‐optimized procedures vs wavefront‐guided procedures

Loss of 1 or more lines of BSCVA at 12 months post treatment · Adults with refractive errors

Wavefront‐optimized procedures showed no clear difference in proportion of eyes that had lost 1 or more lines of best… compared with wavefront‐guided procedures (low certainty).

1 finding from 1 review

Aural toileting vs no aural toileting

Resolution of ear discharge ‐ 4 weeks or more Assessed by: otoscopically confirmed · children with chronic suppurative otitis media

It is very uncertain whether aural toileting changes resolution of ear discharge ‐ 4 weeks or more Assessed by:… compared with no aural toileting (very low certainty).

1 finding from 1 review