Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

618 questions · 646 findings · 79 reviews · Neonatal

No studies found 73 · 11.3%GRADE not reported 29 · 4.5%Very low 145 · 22.4%Low 177 · 27.4%Moderate 173 · 26.8%High 49 · 7.6%

Plastic wrap or bag vs usual care

Hypothermia on admission to NICU: core body temperature < 36.5°C or skin temperature < 36°C · preterm or low birth weight infants

Plastic wrap or bag probably leads to lower hypothermia on admission to NICU: core body temperature < 36.5°C or… compared with routine care (moderate certainty).

1 finding from 1 review

Plastic wrap or bag vs usual care

Hyperthermia on admission to NICU: core body temperature > 37.5°C · preterm or low birth weight infants

Plastic wrap or bag probably leads to higher hyperthermia on admission to NICU: core body temperature > 37.5°C compared with routine care (moderate certainty).

1 finding from 1 review

Plastic wrap or bag vs usual care

Mortality (death within hospital stay or at 6 months' corrected gestation) · preterm or low birth weight infants

Plastic wrap or bag showed no clear difference in mortality (death within hospital stay or at 6 months' corrected… compared with routine care (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Oxygen requirement at 36 weeks' postmenstrual age · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) showed no clear difference in CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) probably leads to lower death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36… compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among survivors)

CLD at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroid (< 2 weeks) probably leads to lower CLD at 36 weeks' PMA compared with placebo (among survivors) (moderate certainty).

1 finding from 1 review

Vitamin A vs no supplementation

Chronic lung disease · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in chronic lung disease (oxygen use at 28 days in survivors) compared with no supplementation (moderate certainty).

2 findings from 1 review