What do systematic reviews say?

Certolizumab pegol 200 mg sc (with or without MTX) vs placebo (with or without MTX)

Certolizumab pegol 200 mg sc (with or without MTX) leads to higher ACR 50% improvement compared with placebo (with or without MTX) (high certainty).

• Certolizumab pegol (CDP870) for rheumatoid arthritis in adults 2017 · Cochrane Headline outcomes only
  RR 3.8 [2.42, 5.95]
  5 studies · 1445 participants
  High

Intervention not reported

• Elevation of the head during intensive care management in people with severe traumatic brain injury 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 20 participants
  Very low

DOAC vs variable dose warfarin

Direct oral anticoagulants (DOAC) probably leads to lower intracranial haemorrhage compared with warfarin (moderate certainty).

• Direct oral anticoagulants versus warfarin for preventing stroke and systemic embolic events among atrial fibrillation… 2017 · Cochrane Headline outcomes only
  RR 0.43 [0.27, 0.69]
  5 studies · 12521 participants
  Moderate

Intervention not reported

• Yoga for stroke rehabilitation 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 22 participants
  Very low

Intervention not reported

• Yoga for stroke rehabilitation 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 47 participants
  Very low

Intervention not reported

• Maintenance immunosuppression for adults undergoing liver transplantation: a network meta‐analysis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Intervention not reported

It is very uncertain whether the intervention changes tacrolimus plus mycophenolate plus glucocorticosteroids (very low certainty).

• Maintenance immunosuppression for adults undergoing liver transplantation: a network meta‐analysis 2017 · Cochrane Headline outcomes only
  HR 0.58 [0.14, 1.91]
  1 study · 195 participants
  Very low

Intervention not reported

The intervention may leads to higher tacrolimus plus sirolimus (low certainty).

• Maintenance immunosuppression for adults undergoing liver transplantation: a network meta‐analysis 2017 · Cochrane Headline outcomes only
  HR 2.76 [1.3, 6.69]
  1 study · 222 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes tacrolimus plus azathioprine (very low certainty).

• Maintenance immunosuppression for adults undergoing liver transplantation: a network meta‐analysis 2017 · Cochrane Headline outcomes only
  HR 0.46 [0.17, 1.15]
  1 study · 97 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes tacrolimus plus everolimus (very low certainty).

• Maintenance immunosuppression for adults undergoing liver transplantation: a network meta‐analysis 2017 · Cochrane Headline outcomes only
  HR 1.43 [0.63, 3.38]
  1 study · 488 participants
  Very low

Lispro vs regular insulin (Different insulin types within similar insulin regimens)

• Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Pre‐mixed insulin (70 NPH/30 REG) vs self‐mixed split dose insulin (Different insulin regimens with similar insulin types used within the regimen)

It is very uncertain whether pre‐mixed insulin (70 NPH/30 REG) changes macrosomia compared with self‐mixed split dose insulin (Different insulin regimens with… (very low certainty).

• Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
  RR 0.49 [0.09, 2.54]
  1 study · 93 participants
  Very low

Insulin injected with a Novolin pen vs insulin injected with a needle or syringe (Different insulin regimens with similar insulin types used within the regimen)

It is very uncertain whether insulin injected with a Novolin pen changes macrosomia compared with insulin injected with a needle or syringe (Different insulin… (very low certainty).

• Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
  RR 0.21 [0.03, 1.76]
  1 study · 93 participants
  Very low

Insulin Aspart (+ NPH) vs human insulin (+ NPH insulin)

The review found no eligible studies for this question.

• Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Insulin Detemir + prandial insulin Aspart vs NPH insulin + prandial insulin Aspart (Different insulin types within similar insulin regimens)

• Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Human insulin vs animal insulin (Different insulin types within similar insulin regimens)

It is very uncertain whether human insulin changes macrosomia compared with animal insulin (Different insulin types within similar insulin… (very low certainty).

• Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
  RR 0.22 [0.01, 4.3]
  1 study · 42 participants
  Very low

Celecoxib vs placebo

Celecoxib probably leads to higher clinical improvement: American College of Rheumatology 20%… compared with placebo (moderate certainty).

• Celecoxib for rheumatoid arthritis 2017 · Cochrane Headline outcomes only
  RR 1.53 [1.25, 1.86]
  2 studies · 873 participants
  Moderate

Celecoxib vs NSAIDs

Celecoxib showed no clear difference in clinical improvement: American College of Rheumatology 20%… compared with traditional NSAIDs (moderate certainty).

• Celecoxib for rheumatoid arthritis 2017 · Cochrane Headline outcomes only
  RR 1.1 [0.99, 1.23]
  4 studies · 1981 participants
  Moderate

Intervention not reported

The review found no eligible studies for this question.

• Enzyme replacement therapy for Anderson‐Fabry disease 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Psychostimulant drugs for cocaine dependence 2016 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 526 participants
  Very low