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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

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No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Summary of findings table ‐ Early developmental intervention programmes vs standard follow‐up

Cognitive outcome · preterm infants
3 findings from 1 review

Exposure vs no exposure to the smell and taste of milk with tube feeds

Late infection during hospitalisation (bacterial or fungal infection confirmed by presence of blood or CSF infection, with initiation of symptoms > 48 hours after birth) · preterm infants

Exposure showed no clear difference in late infection during hospitalisation (bacterial or fungal infection… compared with no exposure to the smell and taste of milk with tube feeds (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Preterm birth · pregnant women

Summary of findings table ‐ Vitamin B12 supplementation showed no clear difference in preterm birth (< 37 weeks) compared with placebo/no vitamin B12 supplementation (low certainty).

1 finding from 1 review

Summary of findings table ‐ ICSI vs c‐IVF

Multiple pregnancy · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in multiple Pregnancy compared with c‐IVF (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ ICSI vs c‐IVF

Ectopic pregnancy · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in ectopic Pregnancy compared with c‐IVF (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ ICSI vs c‐IVF

Prematurity · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in prematurity compared with c‐IVF (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ ICSI vs c‐IVF

Clinical pregnancy · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in clinical Pregnancy compared with c‐IVF (low certainty).

1 finding from 1 review

Summary of findings table ‐ ICSI vs c‐IVF

Viable intrauterine Pregnancy · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in viable intrauterine Pregnancy compared with c‐IVF (moderate certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Depression: meeting study criteria for depression at end of · people with depression after stroke

It is very uncertain whether pharmacological interventions changes depression: meeting study criteria for depression at end of… compared with placebo (very low certainty).

2 findings from 1 review

Non‐invasive brain stimulation vs usual care with or without sham interventions

Depression: meeting study criteria for depression at end of · people with depression after stroke
2 findings from 1 review

Psychological therapy vs usual care or attention control

Depression: meeting study criteria for depression at end of · people with depression after stroke

It is very uncertain whether psychological therapy changes depression: meeting study criteria for depression at end of… compared with usual care and/or attention control (very low certainty).

2 findings from 1 review