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Evidence found and GRADE certainty

1,245 questions · 1,274 findings · 321 reviews

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No studies found 247 · 19.4%GRADE not reported 195 · 15.3%Very low 372 · 29.2%Low 282 · 22.1%Moderate 141 · 11.1%High 37 · 2.9%

Intervention not reported

Any hearing loss defined as 40 dB or more not detected by the better ear during the · children with acute bacterial meningitis

The intervention showed no clear difference in any hearing loss defined as 40 dB or more not detected by the better… (low certainty).

1 finding from 1 review

Intervention not reported

Severe hearing loss defined as a threshold of 60 dB or more in the better ear or requiring bilateral hearing aid during the · children with acute bacterial meningitis

The intervention showed no clear difference in severe hearing loss defined as a threshold of 60 dB or more in the… (low certainty).

1 finding from 1 review

Transepithelial CXL using iontophoresis vs epithelium‐off CXL

Proportion of participants who gained 10 or more logMAR letters from baseline · participants with progressive keratoconus

It is very uncertain whether transepithelial CXL using iontophoresis changes proportion of participants who gained 10 or more logMAR letters from… compared with epithelium‐off CXL (very low certainty).

1 finding from 1 review

Transepithelial CXL using iontophoresis vs epithelium‐off CXL

Proportion of participants who lost 10 or more logMAR letters from baseline · participants with progressive keratoconus

It is very uncertain whether transepithelial CXL using iontophoresis changes proportion of participants who lost 10 or more logMAR letters from… compared with epithelium‐off CXL (very low certainty).

1 finding from 1 review

Supervised maintenance programme following pulmonary rehabilitation vs usual care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · patients with chronic obstructive pulmonary disease

Supervised maintenance programme following pulmonary rehabilitation showed no clear difference in exacerbation: number of people experiencing one or more exacerbation compared with usual care (low certainty).

1 finding from 1 review

High-volume evacuation (HVE) vs No HVE

Reduction in level of contamination in aerosols (CFU) at more than 1 foot from oral cavity (CCT) · People undergoing aerosol-generating procedures (AGPs) in a dental setting

High-volume evacuation (HVE) led to lower reduction in level of contamination in aerosols (CFU) at more than 1… compared with no HVE; GRADE not reported.

1 finding from 1 review

High-volume evacuation (HVE) vs No HVE

Reduction in level of contamination in aerosols (CFU) during ultrasonic scaling and air polishing at more than 1 foot from oral cavity (RCT) · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether high-volume evacuation (HVE) changes reduction in level of contamination in aerosols (CFU) during… compared with no HVE (very low certainty).

1 finding from 1 review

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Number of people with one or more isolates of S aureus (sensitive strains) · children with cystic fibrosis

Summary of findings ‐ Prophylactic may leads to lower number of people with one or more isolates of S aureus (sensitive… compared with 'as required' anti‐staphylococcal antibiotics (low certainty).

1 finding from 1 review

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Number of people with one or more isolates of P aeruginosa · children with cystic fibrosis

Summary of findings ‐ Prophylactic showed no clear difference in number of people with one or more isolates of P aeruginosa compared with 'as required' anti‐staphylococcal antibiotics (low certainty).

1 finding from 1 review

Radiotherapy vs control

Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with neovascular AMD

Radiotherapy showed no clear difference in loss of 3 or more lines of best‐corrected visual acuity Measured… compared with control (low certainty).

1 finding from 1 review

Radiotherapy combined with anti‐VEGF vs anti‐VEGF alone

Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with neovascular AMD

Radiotherapy combined with anti‐VEGF probably leads to higher loss of 3 or more lines of best‐corrected visual acuity Measured… compared with anti‐VEGF alone (moderate certainty).

1 finding from 1 review

Intervention not reported

Use of 1 or more red blood cell transfusions (low and high doses of EPO) · preterm infants with low birth weight

The intervention may leads to lower use of 1 or more red blood cell transfusions (low and high doses of… (low certainty).

1 finding from 1 review