Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,087 questions · 2,360 findings · 390 reviews

No studies found 224 · 9.5%GRADE not reported 603 · 25.6%Very low 555 · 23.5%Low 548 · 23.2%Moderate 312 · 13.2%High 118 · 5%

38% SDF + potassium iodide solution (applied annually) vs Tricalcium silicate (TCS) paste (applied twice daily)

Remineralization/arrest of early enamel carious lesions · Patients with early enamel carious lesions on permanent molars

For early enamel lesions, annual SDF+KI was significantly LESS effective than twice-daily tricalcium silicate paste (54.8% vs 100% arrested; p<0.001; ungraded).

1 finding from 1 review

38% SDF + potassium iodide solution (applied annually) vs CPP-ACP

Remineralization/arrest of early enamel carious lesions · Patients with early enamel carious lesions on permanent molars

For early enamel lesions, annual SDF+KI was significantly less effective than twice-daily CPP-ACP (54.8% vs 100% arrested; p<0.001; ungraded).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Mortality Mortality at latest · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids showed no clear difference in mortality at latest reported age compared with placebo or no treatment (high certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

BPD (36 weeks' PMA) · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids probably leads to lower BPD (36 weeks' PMA) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Death or bronchopulmonary dysplasia at 36 weeks PMA · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids leads to lower mortality or BPD at 36 weeks' PMA compared with placebo or no treatment (high certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Gastrointestinal perforation during primary hospitalisation · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids leads to higher gastrointestinal perforation during primary hospitalisation compared with placebo or no treatment (high certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Cerebral palsy · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids leads to higher cerebral palsy at latest reported age compared with placebo or no treatment (high certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Death or cerebral palsy · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids showed no clear difference in mortality or cerebral palsy at latest reported age compared with placebo or no treatment (high certainty).

1 finding from 1 review

Fluoride varnish vs Untreated lesions (single-arm before vs after proportion)

Remineralisation of early enamel caries · Patients (mainly children) with white spot lesions (WSL)

Professionally applied 5% sodium fluoride varnish remineralised about two-thirds of early enamel caries lesions in children (pooled proportion 63.6%, 95% CI 36.0% to 91.2%; 4 studies); certainty was not GRADE-rated and heterogeneity was very high (I2=96%).

1 finding from 1 review

Fluoride varnish vs No fluoride treatment

Dimensional change (size) of early enamel caries lesions · Patients (mainly children) with white spot lesions (WSL)

In one trial, professionally applied sodium fluoride varnish significantly reduced the size of early enamel caries lesions compared with no fluoride treatment; ungraded.

1 finding from 1 review

1.23% APF gel vs Not specified

Remineralisation of early enamel caries · Children with early (incipient) enamel caries

One trial found acidulated phosphate fluoride gel did not remineralise early enamel caries; ungraded.

1 finding from 1 review

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs Not specified

Remineralisation of early enamel caries · Children with early (incipient) enamel caries

One trial found sodium fluoride gel significantly remineralised early enamel caries; ungraded.

1 finding from 1 review

10% silver diamine fluoride (SDF) vs Glass ionomer restoration and tooth-brushing

Remineralisation of early enamel caries · Children with early enamel caries in erupting permanent first molars

One pilot study found 10% silver diamine fluoride worked about as well as glass ionomer restoration and tooth-brushing for remineralising early enamel caries; ungraded.

1 finding from 1 review

6% sodium fluoride with 6% calcium fluoride varnish vs no treatment

Remineralisation of early enamel caries · Children with early enamel caries (permanent dentition)

One trial found 6% sodium fluoride plus 6% calcium fluoride varnish significantly reversed early enamel caries versus no treatment; ungraded and not meta-analysed.

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ GM501 (specific) versus ISMI (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ GM501 (specific) versus ISMI (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ G2 (specific) versus Universal IVF (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ G2 (specific) versus Universal IVF (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer: Cook (K‐SIFM or K‐SICM) (specific) versus Vitrolife (IVF or G3) (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

The intervention showed no clear difference in early embryo transfer: Cook (K‐SIFM or K‐SICM) (specific) versus… (low certainty).

1 finding from 1 review