Early initiation of epidural analgesia vs Late initiation
- Early versus late initiation of epidural analgesia for labour 2014 · Cochrane Headline outcomes onlyno estimate extracted4 studies · 14004 participantsHigh
For early enamel lesions, annual SDF+KI was significantly LESS effective than twice-daily tricalcium silicate paste (54.8% vs 100% arrested; p<0.001; ungraded).
For early enamel lesions, annual SDF+KI was significantly less effective than twice-daily CPP-ACP (54.8% vs 100% arrested; p<0.001; ungraded).
Early systemic postnatal corticosteroids showed no clear difference in mortality at latest reported age compared with placebo or no treatment (high certainty).
Early systemic postnatal corticosteroids probably leads to lower BPD (36 weeks' PMA) compared with placebo or no treatment (moderate certainty).
Early systemic postnatal corticosteroids leads to lower mortality or BPD at 36 weeks' PMA compared with placebo or no treatment (high certainty).
Early systemic postnatal corticosteroids leads to higher gastrointestinal perforation during primary hospitalisation compared with placebo or no treatment (high certainty).
Early systemic postnatal corticosteroids leads to higher cerebral palsy at latest reported age compared with placebo or no treatment (high certainty).
Early systemic postnatal corticosteroids showed no clear difference in mortality or cerebral palsy at latest reported age compared with placebo or no treatment (high certainty).
Professionally applied 5% sodium fluoride varnish remineralised about two-thirds of early enamel caries lesions in children (pooled proportion 63.6%, 95% CI 36.0% to 91.2%; 4 studies); certainty was not GRADE-rated and heterogeneity was very high (I2=96%).
In one trial, professionally applied sodium fluoride varnish significantly reduced the size of early enamel caries lesions compared with no fluoride treatment; ungraded.
One trial found acidulated phosphate fluoride gel did not remineralise early enamel caries; ungraded.
One trial found sodium fluoride gel significantly remineralised early enamel caries; ungraded.
One pilot study found 10% silver diamine fluoride worked about as well as glass ionomer restoration and tooth-brushing for remineralising early enamel caries; ungraded.
One trial found 6% sodium fluoride plus 6% calcium fluoride varnish significantly reversed early enamel caries versus no treatment; ungraded and not meta-analysed.
It is very uncertain whether the intervention changes early embryo transfer ‐ GM501 (specific) versus ISMI (other) (very low certainty).
It is very uncertain whether the intervention changes early embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) (very low certainty).
It is very uncertain whether the intervention changes early embryo transfer ‐ G2 (specific) versus Universal IVF (other) (very low certainty).
The intervention showed no clear difference in early embryo transfer: Cook (K‐SIFM or K‐SICM) (specific) versus… (low certainty).