Topical antibiotics vs another topical antibiotic or placebo
Adverse effects · children and adults with corneal abrasion
1 finding from 1 review
- no estimate extractedStudies not reportedLow
Findings
What do systematic reviews say?
2,123 questions · 2,188 findings · 243 reviews
No studies found 493 · 22.5%GRADE not reported 160 · 7.3%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.6%High 97 · 4.4%
Topical antibiotics vs no topical antibiotic.
Surgical site infection · people presenting for surgery where healing of surgical wound planned to be by primary intention
Topical antibiotics probably leads to lower surgical site infection compared with no topical antibiotic. (moderate certainty).
1 finding from 1 review
- Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes onlyRR 0.61 [0.42, 0.87]7 studies · 5427 participantsModerate
Topical antibiotics vs no topical antibiotic.
Allergic contact dermatitis · people presenting for surgery where healing of surgical wound planned to be by primary intention
It is very uncertain whether topical antibiotics changes allergic contact dermatitis compared with no topical antibiotic. (very low certainty).
1 finding from 1 review
- Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes onlyRR 3.94 [0.46, 34]3 studies · 3012 participantsVery low
Topical antibiotics vs no topical antibiotic.
Adverse event: anaphylaxis · people presenting for surgery where healing of surgical wound planned to be by primary intention
The review found no eligible studies for this question.
1 finding from 1 review
- Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Topical antibiotics vs no topical antibiotic.
Number of wounds healed · people presenting for surgery where healing of surgical wound planned to be by primary intention
The review found no eligible studies for this question.
1 finding from 1 review
- Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Antibiotics vs no treatment or placebo on top of topical antibiotics
Health‐related quality of life · people (of any age) with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Antibiotics vs no treatment or placebo on top of topical antibiotics
Ear pain (otalgia) or discomfort or local irritation · people (of any age) with CSOM
It is very uncertain whether systemic antibiotics changes ear pain (otalgia) or discomfort or local irritation ‐ measured at 1… compared with no treatment or placebo on top of topical antibiotics (very low certainty).
1 finding from 1 review
- RR 1 [0.21, 4.72]1 study · 100 participantsVery low
Antibiotics vs no treatment or placebo on top of topical antibiotics
Hearing · people (of any age) with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Antibiotics vs no treatment or placebo on top of topical antibiotics
Serious complications ‐ measured at 19 to 24 days · people (of any age) with CSOM
1 finding from 1 review
- no estimate extracted1 study · 40 participantsVery low
Antibiotics vs no treatment or placebo on top of topical antibiotics
Suspected ototoxicity · people (of any age) with CSOM
It is very uncertain whether systemic antibiotics changes suspected ototoxicity ‐ measured at 10 days to 3 weeks compared with no treatment or placebo on top of topical antibiotics (very low certainty).
1 finding from 1 review
- RR 3 [0.13, 71.92]3 studies · 250 participantsVery low
Antibiotics vs no treatment or placebo on top of topical antibiotics
Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with CSOM
Systemic antibiotics showed no clear difference in resolution of ear discharge ‐ measured at 1 to 2 weeks compared with no treatment or placebo on top of topical antibiotics (low certainty).
1 finding from 1 review
- RR 1.02 [0.93, 1.12]5 studies · 390 participantsLow
Antibiotics vs no treatment or placebo on top of topical antibiotics
Resolution of ear discharge ‐ measured after 4 weeks · people (of any age) with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Comparison 1: antibiotic alone or antibiotic with other newborn care interventions vs usual care
Neonatal mortality · neonates with sepsis
Comparison 1: antibiotic alone or antibiotic with other newborn care… showed no clear difference in neonatal mortality ‐ antibiotics alone compared with standard care (moderate certainty).
2 findings from 1 review
- Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes onlyRR 1.07 [0.89, 1.29]1 study · 18747 participantsModerate
- Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes onlyRR 0.76 [0.62, 0.94]4 studies · 106387 participantsModerate
Antibiotics after D&C vs D&C during antibiotics
Absence of fever (degree‐hour) ‐ Clindamycin after D&C versus D&C during clindamycin · patients with treating septic abortion
1 finding from 1 review
- no estimate extracted1 study · 37 participantsModerate
Antibiotics after D&C vs D&C during antibiotics
Absence of fever (degree‐hour) ‐ Penicillin + chloramphenicol after D&C versus D&C during penicillin + chloramphenicol therapy) · patients with treating septic abortion
1 finding from 1 review
- no estimate extracted1 study · 39 participantsModerate
Nebulised antibiotics vs IV antibiotics
FVC (% predicted) Change from baseline · adults and children with cystic fibrosis (during acute exacerbations of lung disease)
1 finding from 1 review
- Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis 2015 · Cochrane Headline outcomes onlyno estimate extracted1 study · 54 participantsVery low
Nebulised antibiotics vs IV antibiotics
Time to next exacerbation · adults and children with cystic fibrosis (during acute exacerbations of lung disease)
The review found no eligible studies for this question.
1 finding from 1 review
- Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis 2015 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Nebulised antibiotics vs IV antibiotics
Quality of life · adults and children with cystic fibrosis (during acute exacerbations of lung disease)
The review found no eligible studies for this question.
1 finding from 1 review
- Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis 2015 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Preoperative antibiotics vs placebo or no antibiotic
Wound infection · breast cancer surgery
Preoperative antibiotics probably leads to lower wound infections Proportion of wound infections compared with placebo or no antibiotic (moderate certainty).
1 finding from 1 review
- Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery 2019 · Cochrane Headline outcomes onlyRR 0.67 [0.53, 0.85]10 studies · 2823 participantsModerate
Preoperative antibiotics vs placebo or no antibiotic
Adverse reactions to treatment Proportion of participants with adverse reactions to treatment · breast cancer surgery
1 finding from 1 review
- Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery 2019 · Cochrane Headline outcomes onlyno estimate extracted10 studies · 2818 participantsVery low