Cochrane · systematic review · CD005360
Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery
Gallagher, M, Jones, DJ, Bell‐Syer, SV · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
WoundsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
6
No studies
4
Included studies
NR
No studies 4 · 40%Ungraded 0 · 0%Very low 2 · 20%Low 3 · 30%Moderate 1 · 10%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Preoperative antibiotics compared with placebo or no antibiotic for breast cancer surgery
Population: breast cancer surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Wound infections Proportion of wound infections Preoperative antibiotics vs placebo or no antibiotic | RR 0.67 [0.53, 0.85] | 10 studies · 2823 participants | Moderate Downgraded: imprecision |
Adverse reactions to treatment Proportion of participants with adverse reactions to treatment Preoperative antibiotics vs placebo or no antibiotic | no estimate extracted | 10 studies · 2818 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Time to onset of infection Mean time to onset of infection Preoperative antibiotics vs placebo or no antibiotic | no estimate extracted | 4 studies · 1450 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Readmission to hospital Proportion of patients readmitted to hospital Preoperative antibiotics vs placebo or no antibiotic | no estimate extracted | 3 studies · 784 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Cost of care Heterogenous cost calculation methodology Preoperative antibiotics vs placebo or no antibiotic | no estimate extracted | 2 studies · 510 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Perioperative antibiotics compared with placebo or no antibiotic for breast cancer surgery
Population: breast cancer surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Wound infection Proportion of wound infections Perioperative antibiotics vs placebo or no antibiotic | RR 0.11 [0.01, 1.95] | 1 study · 44 participants | Very low Downgraded: risk of bias |
Adverse reactions to treatment Perioperative antibiotics vs placebo or no antibiotic | no estimate extracted | NR | No studies |
Time to onset of infection Perioperative antibiotics vs placebo or no antibiotic | no estimate extracted | NR | No studies |
Readmission to hospital Perioperative antibiotics vs placebo or no antibiotic | no estimate extracted | NR | No studies |
Cost of care Perioperative antibiotics vs placebo or no antibiotic | no estimate extracted | NR | No studies |