Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

633 questions · 668 findings · 122 reviews · Headline outcomes only

No studies found 144 · 21.6%GRADE not reported 27 · 4%Very low 154 · 23.1%Low 194 · 29%Moderate 119 · 17.8%High 30 · 4.5%

Patient‐initiated appointment systems vs consultant‐led appointment systems

QoL · adults with a chronic or recurrent condition

Patient‐initiated appointment systems showed no clear difference in patient outcomes: quality of life (different scales used across… compared with consultant‐led appointment systems (low certainty).

1 finding from 1 review

Topical antibiotics with steroids vs topical antibiotics

Serious complications (including intracranial complications, extracranial complications and death) · people (of any age) with chronic suppurative otitis media or ear discharge

The review found no eligible studies for this question.

2 findings from 1 review

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Symptomatic intracranial haemorrhage at

Percutaneous vascular interventions showed no clear difference in symptomatic intracranial haemorrhage within first 14 days compared with intravenous thrombolytic treatment (low certainty).

1 finding from 1 review

POP surgery with concomitant continence procedure vs no concomitant continence procedure

Abdominal POP surgery with or without concomitant continence surgery: additional Burch colposuspension vs sacrocolpopexy alone · women with POP and SUI

POP surgery with concomitant continence procedure showed no clear difference in abdominal POP surgery with vs without concomitant continence… compared with no concomitant continence procedure (moderate certainty).

1 finding from 1 review

Vaginal or abdominal POP surgery with concomitant continence procedure vs no concomitant continence procedure

Abdominal POP surgery with or without concomitant continence surgery: additional Burch colposuspension vs sacrocolpopexy alone · continent women with POP

Vaginal or abdominal POP surgery with concomitant continence procedure showed no clear difference in abdominal POP surgery with or without concomitant continence… compared with no concomitant continence procedure (low certainty).

1 finding from 1 review

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Symptomatic intracranial haemorrhage/haemorrhagic transformation of the cerebral infarct during treatment period (range 6 days to 16 days)⁹ · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids showed no clear difference in symptomatic intracranial haemorrhage/haemorrhagic transformation of… compared with unfractionated heparin (low certainty).

1 finding from 1 review