Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, conventional bitewing radiography (E-speed) pooled sensitivity was 0.48 (95% CI 0.21 to 0.77) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
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All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
In prospective cohorts, the multivariable-adjusted HR for all-cause mortality in edentulous adults (0 teeth) vs adults with 1-32 teeth was 1.30 (95% CI 1.21 to 1.40; 7 studies, I2=20%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
4 findings from 1 review
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Optical/esthetic improvement (visual-tactile assessment) · Patients with post-orthodontic white spot lesions (WSL)
Resin infiltration produced significantly greater optical improvement of white spot lesions than untreated (naturally remineralizing) controls (SMD 1.24, 95% CI 0.59 to 1.88; moderate certainty).
4 findings from 1 review
SMD 1.24 [0.59, 1.88]
3 studies · 949 participants
Moderate
SMD 2.34 [1.68, 3.01]
1 study · 66 participants
GRADE not reported
SMD 0.63 [0.26, 1.01]
1 study · 115 participants
GRADE not reported
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Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
In in vivo, laser fluorescence (DIAGNOdent 2095) pooled diagnostic odds ratio was 18.33 (95% CI 7.57 to 44.37) for occlusal caries at the caries detection level; ungraded.
4 findings from 1 review
DOR 18.33 [7.57, 44.37]
1 study
GRADE not reported
Sensitivity 0.88 [0.81, 0.93]
1 study
GRADE not reported
Specificity 0.71 [0.55, 0.83]
1 study
GRADE not reported
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AUC 0.88
1 study
GRADE not reported
Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)
Under in vitro conditions, sensor-based digital bitewing radiography had a pooled diagnostic odds ratio of 12.84 (95% CI 6.56, 25.13) for proximal caries detection at the dentin detection level; ungraded.
4 findings from 1 review
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Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, visual examination pooled sensitivity was 0.46 (95% CI 0.20 to 0.73) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Sensitivity 0.46 [0.20, 0.73]
8 studies
GRADE not reported
Specificity 0.87 [0.72, 0.95]
8 studies
GRADE not reported
DOR 5.93 [3.11, 11.31]
8 studies
GRADE not reported
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AUC 0.79
8 studies
GRADE not reported
Intervention not reported
Dental caries prevalence · General population (children and adults) in East Africa
The pooled prevalence of dental caries in East Africa (2000-2020) was 45.7% (95% CI 38.0 to 53.4); certainty not graded.
1 finding from 1 review
Water samples with fluoride concentration below the acceptable range · Brazilian cities in the Southeast region with artificially fluoridated public water supplies
In the Southeast region, 24.6% of samples were below the acceptable range.
1 finding from 1 review
Prevalence 24.6
Studies not reported
GRADE not reported
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
In prospective cohorts, adults with 17-24 teeth had a higher cumulative incidence of ACVD-related events than adults with 25-32 teeth (RR 1.73, 95% CI 1.22 to 2.45; 4 cohort studies, I2=87%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
1 finding from 1 review
All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
In prospective cohorts, the crude HR for all-cause mortality in adults with 0-19 teeth vs adults with 20-32 teeth was 2.47 (95% CI 2.40 to 2.54; 2 studies, I2=0%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
4 findings from 1 review
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Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)
Under in vitro conditions, phosphor-plate digital bitewing radiography had a summary ROC AUC of 0.82 for proximal caries detection at the caries detection level; ungraded.
4 findings from 1 review
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Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)
Under in vivo conditions, conventional E-speed bitewing radiography had a pooled specificity of 0.91 (95% CI 0.80, 0.96) for proximal caries detection at the dentin detection level; ungraded.
4 findings from 1 review
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Initiation of white spot lesions (WSL), visual-tactile assessment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Fluoride-releasing coating material did not show a statistically significant reduction in new white spot lesions versus non-fluoride coating (very low certainty).
1 finding from 1 review
Diagnostic accuracy for proximal caries detection (caries detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)
Under in vivo conditions, laser fluorescence (DIAGNOdent 2190) had a summary ROC AUC of 0.96 for proximal caries detection at the caries detection level; ungraded.
4 findings from 1 review
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Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition)
In the low caries-risk subgroup, micro-invasive treatment reduced the odds of lesion progression (OR 0.24, 95% CI 0.08 to 0.72; ungraded subgroup).
9 findings from 1 review
OR 0.24 [0.08, 0.72]
2 studies
GRADE not reported
OR 0.17 [0.10, 0.29]
4 studies
GRADE not reported
OR 0.30 [0.20, 0.45]
5 studies
GRADE not reported
Show 6 more findings
Intervention not reported
Dental caries prevalence
1 finding from 1 review
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, fibre-optic transillumination pooled specificity was 0.97 (95% CI 0.89 to 0.994) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Specificity 0.97 [0.89, 0.994]
2 studies
GRADE not reported
DOR 37.77 [13.69, 104.19]
2 studies
GRADE not reported
AUC 0.92
2 studies
GRADE not reported
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Lactobacilli presence (CFU > 10^5) · Adults undergoing orthodontic treatment
Aligners probably lower the risk of high lactobacilli counts versus fixed appliances in adults at 3 months (RR 0.09, 95% CI 0.02 to 0.47; low certainty).
2 findings from 1 review
Average fluorescence loss (dF%) · Adults undergoing orthodontic treatment
A single study reported lower average fluorescence (mineral) loss with aligners versus fixed appliances in adults at 3 months (MD -1.40, 95% CI -2.15 to -0.65; ungraded).
1 finding from 1 review
MD -1.40 [-2.15, -0.65]
1 study
GRADE not reported
All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for all-cause mortality (11 studies, I2=89%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
3 findings from 1 review