Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Probiotics vs placebo

Proportion of children with AOM (overall) · children up to age 18 years

Probiotic probably leads to lower proportion of children with AOM (overall) compared with placebo (moderate certainty).

1 finding from 1 review

Probiotics vs placebo

Proportion of children with AOM: children not prone to AOM · children up to age 18 years

Probiotic probably leads to lower proportion of children with AOM: children not prone to AOM compared with placebo (moderate certainty).

1 finding from 1 review

Probiotics vs placebo

Proportion of children with AOM: children prone to AOM · children up to age 18 years

Probiotic showed no clear difference in proportion of children with AOM: children prone to AOM compared with placebo (high certainty).

1 finding from 1 review

Probiotics vs placebo

Difference in proportion of children with other infections · children up to age 18 years

Probiotic probably leads to lower difference in proportion of children with other infections compared with placebo (moderate certainty).

1 finding from 1 review

Miswak (Salvadora persica) stick vs Chlorhexidine mouthwash

Patient self-assessment VAS (scale 0 to 10) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether miswak (Salvadora persica) stick changes patient self-assessment VAS (scale 0 to 10) compared with chlorhexidine mouthwash (very low certainty).

1 finding from 1 review

Chlorine dioxide mouthrinse (with tongue scraping) vs Chlorhexidine mouthwash (with tongue scraping)

VSC: hydrogen sulphide · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Chlorine dioxide mouthrinse (with tongue scraping) showed no clear difference in VSC: hydrogen sulphide compared with chlorhexidine mouthwash (with tongue scraping); GRADE not reported.

1 finding from 1 review

Protease cysteine + actinidine tablets vs placebo (3 tablets/4 times a day

Volatile sulphur compounds (VSC), gas chromatography · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Protease cysteine + actinidine tablets showed no clear difference in volatile sulphur compounds (VSC), OralChroma compared with placebo tablets; GRADE not reported.

1 finding from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Volatile sulphur compounds (VSC), gas chromatography · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    Niles 1999 (cross-over trial) compared 0.3% triclosan + 2.0% PVM/MA + 0.243% NaF toothpaste versus placebo toothpaste; VSC by gas chromatograph. We could not use the results in the meta-analysis as there was no…
    1 study
    GRADE not reported

Chlorine dioxide mouthrinse (with tongue scraping) vs Chlorhexidine mouthwash (with tongue scraping)

Adverse events · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    1 week
    Wirthlin 2011 reported altered taste sensation as the adverse event. OLT scores could not be included in the analysis as the group-wise data were not given.
    1 study · 22 participants
    GRADE not reported

Mouthwash (amine/stannous fluoride; or chlorhexidine + cetylpyridinium + zinc) vs Chlorhexidine mouthwash or tap water

OLT and VSC scores · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    7 days
    Wigger-Alberti 2010 mouthwash data (ASF; CHX + CPC + Zn; CHX; tap water) were calculated from a graph (Additional Table 1) but not included, as the report did not give details of sample size per group.
    1 study
    GRADE not reported

Pycnogenol chewing gum vs Placebo chewing gum

VSC: methyl mercaptan · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Pycnogenol chewing gum showed no clear difference in VSC: methyl mercaptan compared with placebo chewing gum; GRADE not reported.

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 1450 to 1500 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 1450 to 1500 ppm F toothpaste (low certainty).

1 finding from 1 review

Chlorhexidine + zinc acetate mouthwash vs Placebo mouthwash

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether chlorhexidine + zinc acetate mouthwash changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with placebo mouthwash (very low certainty).

1 finding from 1 review