Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,888 questions · 2,009 findings · 352 reviews

No studies found 224 · 11.1%GRADE not reported 265 · 13.2%Very low 551 · 27.4%Low 540 · 26.9%Moderate 311 · 15.5%High 118 · 5.9%

Early systemic postnatal corticosteroids vs placebo or no treatment

BPD (36 weeks' PMA) · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids probably leads to lower BPD (36 weeks' PMA) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Death or bronchopulmonary dysplasia at 36 weeks PMA · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids leads to lower mortality or BPD at 36 weeks' PMA compared with placebo or no treatment (high certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Gastrointestinal perforation during primary hospitalisation · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids leads to higher gastrointestinal perforation during primary hospitalisation compared with placebo or no treatment (high certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Cerebral palsy · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids leads to higher cerebral palsy at latest reported age compared with placebo or no treatment (high certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Death or cerebral palsy · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids showed no clear difference in mortality or cerebral palsy at latest reported age compared with placebo or no treatment (high certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ GM501 (specific) versus ISMI (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ GM501 (specific) versus ISMI (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ G2 (specific) versus Universal IVF (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ G2 (specific) versus Universal IVF (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer: Cook (K‐SIFM or K‐SICM) (specific) versus Vitrolife (IVF or G3) (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

The intervention showed no clear difference in early embryo transfer: Cook (K‐SIFM or K‐SICM) (specific) versus… (low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ G2 (specific) versus Ham's F10 (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ G2 (specific) versus Ham's F10 (other) (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Early amino acids vs Late amino acids

Growth during the first month of life · preterm born neonates
3 findings from 1 review

Summary of findings table ‐ Early amino acids vs Late amino acids

Neurodevelopmental outcomes · preterm born neonates

Summary of findings table ‐ Early amino acids showed no clear difference in neurodevelopmental outcome assessed by any standard tool compared with late amino acids (low certainty).

1 finding from 1 review

Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution

All‐cause mortality · febrile neutropenia

Early discontinuation of antibiotic treatment showed no clear difference in mortality compared with treatment until neutropenia resolution (low certainty).

1 finding from 1 review

Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution

Clinical failure · febrile neutropenia

It is very uncertain whether early discontinuation of antibiotic treatment changes clinical failure compared with treatment until neutropenia resolution (very low certainty).

1 finding from 1 review

Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution

Bacteraemia · febrile neutropenia

It is very uncertain whether early discontinuation of antibiotic treatment changes any bacteraemia compared with treatment until neutropenia resolution (very low certainty).

1 finding from 1 review

Extended specialised early intervention (SEI) teams vs standard SEI teams plus treatment

Global state: recovery (assessed by symptom remission over a specified time period, as defined by study) · recent‐onset psychosis

It is very uncertain whether extended specialised early intervention (SEI) teams changes global state: recovery (assessed by symptom remission over a… compared with standard SEI teams plus treatment (very low certainty).

1 finding from 1 review

Extended specialised early intervention (SEI) teams vs standard SEI teams plus treatment

Service use: disengagement from services(assessment varied) · recent‐onset psychosis

Extended specialised early intervention (SEI) teams may leads to lower service use: disengagement from services(assessment varied) compared with standard SEI teams plus treatment (low certainty).

1 finding from 1 review