Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Intervention NR
A 22% reduction in injurious crashes in first year and 20% in second year post intervention compared to before.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRLow
Intervention NR
A non‐significant 19% reduction in crashes (not defined) A 20% reduction in injury crashes 2 years post intervention
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRLow
Intervention NR
After accounting for all potential confounders, the overall average effect of speed cameras on crashes was a reduction of 25% in personal injury crashes (PIA's) and an average 11% reduction in fatal and serious crashes for the 500m monitoring leng...
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRHigh
Intervention NR
At camera sites a reduction of 19% for all crashes and a reduction of 44% for fatal and serious crashes. The authors state that the reduction in total crashes was significantly greater than that expected from the effect of RTM in 12 out of the 20 ...
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRHigh
Intervention NR
Reduction of 50% in personal injury accidents (0‐500m route)
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRLow
Intervention NR
Main findings= 5.8km/h reduction in mean speeds at 24 months at camera sites. For percentage exceeding speed limit, a 70% reduction at camera sites and a 20.9% reduction downstream at 12 months. These reductions were maintained at 24 months. For p...
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRLow
Intervention NR
A significant 56% reduction in fatal crashes relative to controls, a 12% reduction for all crashes and a 25% for serious crashes.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRLow
Intervention NR
23% reduction in number of injury crashes. 66% reduction in fatal crashes.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRLow
Intervention NR
Aggregate change in crashes was a significant 12% reduction for experimental roads.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRHigh
Intervention NR
A reduction of 35% in the total number of crashes for phase 1 and 2 compared to the control roads and the same period 3 years previously.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRLow
Intervention NR
Phase 3 ‐ conducted in 1994 on one road in one province Noord‐Brabant. The reduction in crashes found in 1991 had been maintained.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRNo studies
Intervention NR
A significant 20% reduction in injury crashes equating to about 62 injury crashes per year on all 64 road sections combined.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRHigh
Intervention NR
Reduction of 9.17% in crashes and a significant 32.4% in serious injury compared to New Zealand overall.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRModerate
Intervention NR
Total crash reduction at enforcement zones of 44 to 55%, injury crash reduction of 46 to 56% with no reduction seen in rear‐end crashes
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRHigh
Intervention NR
Total aggregate crash reduction of 12% on experimental corridors
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRModerate
Intervention NR
Phase 1 ‐ General effects ‐ effect of speed camera program on crash rate and severity covering first twelve month post intervention period. Phase 3, 4 and 5, of this 5‐phase study did not have before‐after data, hence only phase 1 and 2 tabled.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Reduction in speed and narrowing of speed distribution for 60km/h, 70km/h and 100km/h zones at experimental sites. No further information given.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRHigh
Intervention NR
Phase 2 ‐ Impact of program mechanisms i.e. number of traffic infringement notices (tin's) hours of speed camera operations, amount of paid TV publicity, demerit points in relation to, injury crash incidence and severity during low alcohol times o...
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRHigh
Intervention NR
Proportion of speeding vehicles in May 1996 (before) at photo radar sites was 66%. By July 1997(after) it was about 35%. At control sites speeding vehicles in September 1995 was about 73%, in November 1996 it was about 61%.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRLow
Intervention NR
About 25% reduction in crashes to that expected. A significant 11% reduction in number of victims, with an average decrease of 139 daytime traffic crashes requiring an ambulance. A 17% reduction in daytime crash fatalities.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Outcome measures were numbers of road crashes, numbers of people injured (combined fatal and non‐fatal) and number of vehicles involved in crashes. The relative risk of a road crash after implementation was 0.73 (5% CI = 0.63, 0.85) This effect wa...
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRHigh
Intervention NR
A 45.74% reduction in weighted injury crashes within 250 metres from camera sites (total monthly before count of 23.4 compared to total monthly after count of 12.7) with lesser but still significant decreases observed in the wider surrounding area...
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRModerate
Intervention NR
Speed outcomes measured: Mean speed, 85th percentile speed, percentage of vehicles over the speed limit and percentage exceeding the speed limit by more than 15mph. Speed results across all new camera sites included a 2.3mph reduction (6% reductio...
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRModerate
Intervention NR
A 30% reduction in vehicles exceeding the speed limit, and a 43% reduction in vehicles exceeding the speed limit by more than 15 mph. Time over distance cameras were shown to be particularly effective (around 100% reduction) at reducing speeds exc...
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Crash outcomes measured: Killed and seriously injured (KSIs) and personal injury crashes (PICs). Across all sites KSI's decreased by 42%. This equated to about 1700 fewer KSI's per annum at these camera sites. Fixed cameras in both urban (47% redu...
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Over the first 2 years of the study mean speeds fell by 1.3 km/h (‐2.6 to 0.1) and 85th percentile speeds reduced by 4.3 km/h on open roads generally,compared with the rest of the country.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRModerate
Intervention NR
Having controlled for season and general trends, injury crash outcomes in experimental areas relative to control areas were a net reduction of 11% (p= 0.03) in all crashes and 19% (p=0.002) in injury crashes on open roads across the region associa...
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Sharp reduction of 5 km/h in median speed on experimental roads after program launch. No further reduction observed despite intensified enforcement. However reduction sustained throughout the 15 month trial period.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRModerate
Intervention NR
Significant average 3.6 km/h decrease in mean speed compared to before. No time halo effect seen.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRModerate
Intervention NR
Net 3.4% speed reduction after consideration of changes in average speeds that occurred at control site during the same before‐after periods. The proportion of drivers exceeding the 80km/h posted speed limit decreased by a net 66%. For speeders ov...
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRHigh
Intervention NR
A reduction from 66% to 35% in the percentage of speeding drivers at experimental sites compared to before period.
Speed cameras for the prevention of road traffic injuries and deaths (2010) · Cochrane
no estimate extractedNRLow
Glatiramer acetate vs placebo
Patients who progressed ‐ at 2 years · patients with multiple sclerosis
Glatiramer acetate for multiple sclerosis (2010) · Cochrane
RR 0.75 [0.51, 1.12]2 studies · 299 participantsUngraded
Glatiramer acetate vs placebo
Patients who progressed ‐ at 35 months · patients with multiple sclerosis
Glatiramer acetate for multiple sclerosis (2010) · Cochrane
RR 0.81 [0.5, 1.29]1 study · 203 participantsUngraded
Glatiramer acetate vs placebo
Change in disability score at the end of · patients with multiple sclerosis
Glatiramer acetate for multiple sclerosis (2010) · Cochrane
no estimate extracted2 studies · 301 participantsUngraded
Glatiramer acetate vs placebo
Change in disability score at the end of · patients with multiple sclerosis
Glatiramer acetate for multiple sclerosis (2010) · Cochrane
no estimate extracted1 study · 203 participantsUngraded
Glatiramer acetate vs placebo
Mean number of relapses ‐ within 1 year of · patients with multiple sclerosis
Glatiramer acetate for multiple sclerosis (2010) · Cochrane
no estimate extracted2 studies · 287 participantsUngraded
Glatiramer acetate vs placebo
Mean number of relapses ‐ at 2 years of · patients with multiple sclerosis
Glatiramer acetate for multiple sclerosis (2010) · Cochrane
no estimate extracted2 studies · 298 participantsUngraded
SoF vitamin E vs placebo
Frequency of hot flushes Number of hot flushes per day ( · patients with hot flushes in women with a history of breast cancer
Non‐hormonal interventions for hot flushes in women with a history of breast cancer (2010) · Cochrane
no estimate extracted1 study · 104 participantsHigh
SoF vitamin E vs placebo
Hot flushes score Number of HF x severity (from 1 to 4) ( · patients with hot flushes in women with a history of breast cancer
Non‐hormonal interventions for hot flushes in women with a history of breast cancer (2010) · Cochrane
no estimate extracted1 study · 104 participantsHigh
SoF gabapentin vs placebo
Frequency of hot flushes Number of hot flushes per day ( · patients with hot flushes in women with a history of breast cancer
Non‐hormonal interventions for hot flushes in women with a history of breast cancer (2010) · Cochrane
no estimate extracted1 study · 233 participantsHigh
SoF gabapentin vs placebo
Hot flushes score Number of HF x severity (from 1 to 4) ( · patients with hot flushes in women with a history of breast cancer
Non‐hormonal interventions for hot flushes in women with a history of breast cancer (2010) · Cochrane
no estimate extracted1 study · 233 participantsHigh
Benzodiazepine vs Placebo
Alcohol withdrawal seizures objective · patients with alcohol withdrawal
Benzodiazepines for alcohol withdrawal (2010) · Cochrane
RR 0.16 [0.04, 0.69]3 studies · 324 participantsModerate
Benzodiazepine vs Placebo
Adverse events · patients with alcohol withdrawal
Benzodiazepines for alcohol withdrawal (2010) · Cochrane
RR 3.28 [0.31, 34.52]2 studies · 71 participantsLow
Benzodiazepine vs Placebo
Dropouts · patients with alcohol withdrawal
Benzodiazepines for alcohol withdrawal (2010) · Cochrane
RR 0.68 [0.38, 1.24]3 studies · 312 participantsModerate
Benzodiazepine vs Other Drug for
Alcohol withdrawal seizures ‐ Benzodiazepine vs. Other Drug · patients with
Benzodiazepines for alcohol withdrawal (2010) · Cochrane
RR 0.52 [0.21, 1.31]12 studies · 1228 participantsModerate
Benzodiazepine vs Other Drug for
Alcohol withdrawal seizures ‐ Benzodiazepine vs. Anticonvulsant · patients with
Benzodiazepines for alcohol withdrawal (2010) · Cochrane
RR 1.7 [0.39, 7.37]7 studies · 523 participantsModerate
Benzodiazepine vs Other Drug for
Adverse events ‐ Benzodiazepine vs. Other Drug · patients with
Benzodiazepines for alcohol withdrawal (2010) · Cochrane
RR 1.31 [0.99, 1.72]18 studies · 919 participantsLow
Benzodiazepine vs Other Drug for
Adverse events ‐ Benzodiazepine vs. Anticonvulsant · patients with
Benzodiazepines for alcohol withdrawal (2010) · Cochrane
RR 1.5 [0.83, 2.7]9 studies · 471 participantsHigh
Benzodiazepine vs Other Drug for
Dropouts ‐ Benzodiazepine vs. Other Drug · patients with
Benzodiazepines for alcohol withdrawal (2010) · Cochrane
RR 0.93 [0.7, 1.24]22 studies · 1848 participantsModerate
Benzodiazepine vs Other Drug for
Dropouts ‐ Benzodiazepine vs. Anticonvulsant · patients with
Benzodiazepines for alcohol withdrawal (2010) · Cochrane
RR 1.11 [0.75, 1.63]11 studies · 839 participantsHigh