Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Intervention not reported

On‐study mortality Death occurring up to 30 days after active study protocol · patients with cancer

The intervention leads to higher on‐study mortality Death occurring up to 30 days after active study… (high certainty).

1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding Number of days with significant bleeding ‐ Low dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder
1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding: Number of days with significant bleeding ‐ High dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder
1 finding from 1 review

Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion

Bleeding: Number of days on which a significant bleeding event occurred3 · People with a haematological disorder

Prophylactic platelet transfusion showed no clear difference in bleeding: Number of days on which a significant bleeding event… compared with non prophylactic or therapeutic platelet transfusion (low certainty).

1 finding from 1 review

Intervention not reported

Analgesic consumption (day 2) post‐operative · Patients with haemorrhoids

The intervention probably leads to lower analgesic consumption (day 2) post‐operative (moderate certainty).

1 finding from 1 review

Human recombinant activated protein C vs placebo

28‐Day all‐cause mortality (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in 28‐Day all‐cause mortality (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

Human recombinant activated protein C vs placebo

Serious bleeding events in adult and paediatric patients (days 0 to 28) · patients with severe sepsis or septic shock

Human recombinant activated protein C probably leads to higher serious bleeding events in adult and paediatric patients (days 0 to… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Recombinant activated factor VII vs placebo

Mortality within 5 days · patients with upper gastrointestinal bleeding and liver diseases.

Recombinant human factor VII activated showed no clear difference in mortality within 5 days compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Recombinant activated factor VII vs placebo

Mortality within 42 days · patients with upper gastrointestinal bleeding and liver diseases.

Recombinant human factor VII activated showed no clear difference in mortality within 42 days compared with placebo (moderate certainty).

1 finding from 1 review

Social cognitive theory for promotion of condom use vs no intervention

Consistent application of condom by FSWs · sex workers

Social cognitive theory for promotion of condom use showed no clear difference in consistent condom use by FSWs with clients in the past 7‐day compared with no intervention (moderate certainty).

1 finding from 1 review

Human deoxyribonuclease vs placebo

Clinical failure Number of children with no significant improvement in cough diary scores at two weeks (average of day 13 to 14) · children with primary (intrinsic) tracheomalacia

Human deoxyribonuclease showed no clear difference in clinical failure Number of children with no significant improvement… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Inpatient and 30 day mortality ‐ Colon cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes inpatient and 30 day mortality ‐ Colon cancer (very low certainty).

1 finding from 1 review

Intervention not reported

Inpatient and 30 day mortality ‐ Rectal cancer · Patients with outcomes after colorectal cancer surgery

The intervention showed no clear difference in inpatient and 30 day mortality ‐ Rectal cancer (low certainty).

1 finding from 1 review

Intervention not reported

Inpatient and 30 day mortality ‐ Colorectal cancer · Patients with outcomes after colorectal cancer surgery

The intervention may leads to lower inpatient and 30 day mortality ‐ Colorectal cancer (low certainty).

1 finding from 1 review

Intervention not reported

Inpatient and 30 day mortality ‐ Colorectal cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes inpatient and 30 day mortality ‐ Colorectal cancer (very low certainty).

1 finding from 1 review