Cochrane · systematic review · CD005304
Interventions for primary (intrinsic) tracheomalacia in children
Goyal, V, Masters, IB, Chang, AB · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Human deoxyribonuclease versus placebo for primary (intrinsic) tracheomalacia in children
Population: children with primary (intrinsic) tracheomalacia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical failure Number of children with no significant improvement in cough diary scores at two weeks (average of day 13 to 14) Human deoxyribonuclease vs placebo | OR 1.38 [0.37, 5.14] | 1 study · 38 participants | Low Downgraded: imprecision |
Daytime cough diary scores (change from baseline) Human deoxyribonuclease vs placebo | no estimate extracted | 1 study · 38 participants | Low Downgraded: imprecision |
Night time cough diary score (change from baseline) Human deoxyribonuclease vs placebo | no estimate extracted | 1 study · 38 participants | Low Downgraded: imprecision |
Night time VAS (change from baseline) Human deoxyribonuclease vs placebo | no estimate extracted | 1 study · 38 participants | Low Downgraded: imprecision |
Difficulty expectorating sputum score (change from baseline) Human deoxyribonuclease vs placebo | no estimate extracted | 1 study · 38 participants | Low Downgraded: imprecision |
Lung function: FVC % predicted (baseline to end point) Human deoxyribonuclease vs placebo | no estimate extracted | 1 study · 27 participants | Low Downgraded: imprecision |
Lung function: FEV1 % predicted (baseline to end point) Human deoxyribonuclease vs placebo | no estimate extracted | 1 study · 27 participants | Low Downgraded: imprecision |