Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Pneumatic retinopexy vs scleral buckle

Proportion of eyes with final BCVA 20/40 or better at 6 months · people with simple rhegmatogenous retinal detachments

Pneumatic retinopexy may leads to higher proportion of eyes with final BCVA 20/40 or better at 6 months compared with scleral buckle (low certainty).

1 finding from 1 review

Fibrinogen concentrate vs any comparator

Incidence of allogenic blood transfusion Proportion of participants transfused with RBC, FFP, PLT and/or cryo · bleeding patients or at risk of severe bleeding

It is very uncertain whether fibrinogen concentrate changes incidence of allogenic blood transfusion Proportion of participants… compared with any comparator (very low certainty).

1 finding from 1 review

Fibrinogen concentrate vs any comparator

Thrombotic episodes (arterial and venous graft occlusion, pulmonary embolus, deep venous thrombosis) Proportion with event · bleeding patients or at risk of severe bleeding

It is very uncertain whether fibrinogen concentrate changes thrombotic episodes (arterial and venous graft occlusion, pulmonary… compared with any comparator (very low certainty).

1 finding from 1 review

Fibrinogen concentrate vs any comparator

Re‐operation due to persistent bleeding Events during admission · bleeding patients or at risk of severe bleeding

It is very uncertain whether fibrinogen concentrate changes re‐operation due to persistent bleeding Events during admission compared with any comparator (very low certainty).

1 finding from 1 review

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Antibiotic resistance: change from baseline in P aeruginosa CFU/g of sputum at week 24 · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review

Summary of findings: anti‐pseudomonal antibiotics vs placebo

Antibiotic resistance: frequency of tobramycin‐resistant P aeruginosa · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: anti‐pseudomonal antibiotics showed no clear difference in antibiotic resistance: frequency of tobramycin‐resistant P aeruginosa compared with placebo (moderate certainty).

1 finding from 1 review

Binocular iPad treatment vs occlusion therapy

Visual acuity · 5‐ to 8‐year‐old children with amblyopia
2 findings from 1 review